| Description : |
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
80.6 kDa |
| AA Sequence : |
MAKREDSPGPEVQPMDKQFLVCSIC LDRYQCPKVLPCLHTFCERCLQNYI PAQSLTLSCPVCRQTSILPEQGVSA LQNNFFISSLMEAMQQAPDGAHDPE DPHPLSVVAGRPLSCPNHEGKTMEF YCEACETAMCGECRAGEHREHGTVL LRDVVEQHKAALQRQLEAVRGRLPQ LSAAIALVGGISQQLQERKAEALAQ ISAAFEDLEQALQQRKQALVSDLET ICGAKQKVLQSQLDTLRQGQEHIGS SCSFAEQALRLGSAPEVLLVRKHMR ERLAALAAQAFPERPHENAQLELVL EVDGLRRSVLNLGALLTTSATAHET VATGEGLRQALVGQPASLTVTTKDK DGRLVRTGSAELRAEITGPDGTRLP VPVVDHKNGTYELVYTARTEGELLL SVLLYGQPVRGSPFRVRALRPGDLP PSPDDVKRRVKSPGGPGSHVRQKAV RRPSSMYSTGGKRKDNPIEDELVFR VGSRGREKGEFTNLQGVSAASSGRI VVADSNNQCIQVFSNEGQFKFRFGV RGRSPGQLQRPTGVAVDTNGDIIVA DYDNRWVSIFSPEGKFKTKIGAGRL MGPKGVAVDRNGHIIVVDNKSCCVF TFQPNGKLVGRFGGRGATDRHFAGP HFVAVNNKNEIVVTDFHNHSVKVYS ADGEFLFKFGSHGEGNGQFNAPTGV AVDSNGNIIVADWGNSRIQVFDSSG SFLSYINTSAEPLYGPQGLALTSDG HVVVADAGNHCFKAYRYLQTRTRPL EQKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
