Recombinant Human TUBG1

• Cat.No.: TUBG1-31632TH
• Product Overview: Recombinant full length Human TUBG1 with a proprietary tag.

Specification

• Description: This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7.
• Protein length: 452 amino acids
• Molecular Weight: 75.720kDa inclusive of tags
• Source: Wheat germ
• Biological activity: useful for Antibody Production and Protein Array
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Glutathione is reduced.
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MPREIITLQLGQCGNQIGFEFWKQL CAEHGISPEGIVEEFATEGTDRKDV FFYQADDEHYIPRAVLLDLEPRVIH SILNSPYAKLYNPENIYLSEHGGGA GNNWASGFSQGEKIHEDIFDIIDRE ADGSDSLEGFVLCHSIAGGTGSGLG SYLLERLNDRYPKKLVQTYSVFPNQ DEMSDVVVQPYNSLLTLKRLTQNAD CVVVLDNTALNRIATDRLHIQNPSF SQINQLVSTIMSASTTTLRYPGYMN NDLIGLIASLIPTPRLHFLMTGYTP LTTDQSVASVRKTTVLDVMRRLLQP KNVMVSTGRDRQTNHCYIAILNIIQ GEVDPTQVHKSLQRIRERKLANFIP WGPASIQVALSRKSPYLPSAHRVSG LMMANHTSISSLFERTCRQYDKLRK REAFLEQFRKEDMFKDNFDEMDTSR EIVQQLIDEYHAATRPDYISWGTQE Q
• Sequence Similarities: Belongs to the tubulin family.
• Tag: Non

Gene Information

• Gene Name: TUBG1 tubulin, gamma 1 [ Homo sapiens ]
• Official Symbol: TUBG1
• Synonyms: TUBG1; tubulin, gamma 1; TUBG, tubulin, gamma polypeptide; tubulin gamma-1 chain; TUBGCP1
• Gene ID: 7283
• mRNA Refseq: NM_001070
• Protein Refseq: NP_001061
• MIM: 191135
• Uniprot ID: P23258
• Chromosome Location: 17q21.31
• Pathway: Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; G2/M Transition, organism-specific biosystem; Loss of Nlp from mitotic centrosomes, organism-specific biosystem; Loss of proteins required for interphase microtubule organization??from the centrosome, organism-specific biosystem
• Function: GTP binding; GTPase activity; nucleotide binding; protein binding; structural constituent of cytoskeleton

Reviews

01/31/2023

The activity is strong, and the experimental effect is obvious.

09/17/2022

Enzyme activity and receptor binding activity are very good.

09/22/2020

The consistency is good, and the results of multiple experiments are highly reproducible.

Q&As

What are the limitations of studies on TUBG1?

There are still some limitations in the current research on TUBG1, such as the lack of in-depth research on its specific mechanism of action and function, and the incomplete understanding of its relationship with diseases. In addition, since TUBG1 is an important component of the cytoskeleton, its regulation may also have some side effects.

Is there a relationship between the expression level of TUBG1 and disease?

Studies have shown that the expression level of TUBG1 is associated with some neurological diseases. For example, in the brains of patients with Alzheimer's disease (AD), the expression levels of TUBG1 are downregulated, which can lead to neuronal damage and death. In some tumors, the expression level of TUBG1 is upregulated, which may promote the proliferation and metastasis of tumor cells.

How can the expression level of TUBG1 be measured?

The expression level of TUBG1 can be detected by immunohistochemistry, western blotting, real-time PCR and other methods. These methods can detect protein or mRNA levels of TUBG1 in tissues or cells to assess changes in its expression in disease.

What new mechanisms or functions have been identified in recent studies of TUBG1?

Recent studies have found that TUBG1 is also involved in cell cycle regulation and DNA repair processes. These processes have an important impact on the survival and death of cells, and also provide new ideas for the treatment of some diseases related to TUBG1.

What is the treatment strategy for TUBG1?

Therapeutic strategies for TUBG1 include modulating its expression levels, inhibiting its activity, or using gene therapy. For example, some studies have shown that the use of microtubule stabilizers can increase the expression level and activity of TUBG1, thereby treating some TUBG1-related neurological diseases.

Is TUBG1 related to other genes or proteins?

TUBG1 has complex relationships with other genes or proteins. For example, it interacts with other members of the tubulin family to form microtubules. In addition, TUBG1 is regulated by a number of transcription factors and signal transduction pathways.