Recombinant Human Tumor Necrosis Factor TNF-194H

Recombinant Human Tumor Necrosis Factor

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Cat.No. : TNF-194H Optional Service: Optional requirements on this protein
Product Overview : Recombinant human TNF-α was expressed inE.coliand purified by using conventional chromatography techniques. Additional amino acid, methionine, was attached at N-terminus of the protein. MW=17.5kDa (158 aa).
Description : Tumor necrosis factor alpha (TNF-α), also called cachectin, consists of 157 amino acids. TNF-α is a 17.5kD factor produced by neutrophils, CD4+ T cells, macrophage, NK cells, LAK cells, astrocytes endothelial cells, and smooth muscle cells. TNF-α is cytolytic and plays an important role in immune regulation including hemorrhagic tumor necrosis/cytotoxicity and inflammation, and in regulation of antiviral and immune proliferative and activation responses. The active form of this protein is a trimer.
Source : Escherichia Coli.
Amino Acids Sequences : MVRSSSRTPS DKPVAHVVAN PQAEGQLQWL NRRANALLAN GVELRDNQLV VPSEGLYLIY SQVLFKGQGC PSTHVLLTHT ISRIAVSYQT KVNLLSAIKS PCQRETPEGA EAKPWYEPIY LGGVFQLEKG DRLSAEINRP DYLDFAESGQ VYFGIIAL
Purity : > 95% by SDS–PAGE.
Concentration : 1mg/ml (determined by Bradford assay).
Form : Liquid. In PBS buffer (pH7.4).
Endotoxin Level : < 1.0EU per 1 μg of protein (determined by LAL method).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
PDB rendering based on 1TNF. :

Gene Name : TNF tumor necrosis factor (TNF superfamily, member 2) [ Homo sapiens ]
Synonyms : TNF; tumor necrosis factor (TNF superfamily, member 2); DIF; TNFA; TNFSF2; TNF-alpha; Tumor necrosis factor; Tumor necrosis factor ligand; TNF-a; Cachectin; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; superfamily member 2; OTTHUMP00000029281; OTTHUMP00000037669; cachectin; APC1 protein; TNF superfamily, member 2; TNF, macrophage-derived; TNF, monocyte-derived; Tumor necrosis factor ligand superfamily member 2; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha
Gene ID : 7124
mRNA Refseq : NM_000594
Protein Refseq : NP_000585
MIM : 191160
UniProt ID : P01375
Chromosome Location : 6p21.3
Pathway : receptor interaction; Fc epsilon RI signaling pathway; Graft-versus-host disease; Hypertrophic cardiomyopathy (HCM); Hematopoietic cell lineage; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; RIG-I-like receptor signaling pathway; Systemic lupus erythematosus; T cell receptor signaling pathway; TGF-beta signaling pathway; Toll-like receptor signaling pathway; Type I diabetes mellitus; Type II diabetes mellitus; Apoptosis; Hematopoietic cell lineage
Function : cytokine activity; identical protein binding; tumor necrosis factor receptor binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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