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Recombinant Human TYMS protein, MYC/DDK-tagged

Cat.No. : TYMS-684H
Product Overview : Recombinant Human TYMS fused with MYC/DDK tag at C-terminal was expressed in HEK293.
Description : Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 35.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : TYMS thymidylate synthetase [ Homo sapiens ]
Official Symbol : TYMS
Synonyms : TYMS; thymidylate synthetase; TS; thymidylate synthase; HsT422; TMS; Tsase; TSase; HST422; MGC88736;
Gene ID : 7298
mRNA Refseq : NM_001071
Protein Refseq : NP_001062
MIM : 188350
UniProt ID : P04818
Chromosome Location : 18p11.31-p11.21
Pathway : Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; E2F mediated regulation of DNA replication, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem; G1/S Transition, organism-specific biosystem; G1/S-Specific Transcription, organism-specific biosystem;
Function : cofactor binding; folic acid binding; methyltransferase activity; nucleotide binding; thymidylate synthase activity; thymidylate synthase activity; transferase activity;

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