Recombinant Human UBE2R2, His-tagged
Cat.No. : | UBE2R2-209H |
Product Overview : | Recombinant human UBE2R2 (UBC3B) (2-end) was expressed in E. coli cells using an N-terminal His tag. |
- Specification
- Gene Information
- Related Products
Description : | UBE2R2 (UBC3B) or ubiquitin-conjugating enzyme E2R 2 encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP therby enhancing beta-catenin degradation. CK2-dependent phosphorylation of CDC34 and UBC3B functions by regulating BTRC substrate recognition. UBE2R2 complements a yeast cdc34 temperature-sensitive mutant. Deletion and site-directed mutagenesis demonstrated that CK2 phosphorylated UBE2R2 in the C-terminal domain at serine-233; mutagenesis of the corresponding serine residue at position 231 of human CDC34/UBC3 showed that this was the major CK2-phosphorylation site in this protein. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Molecular Mass : | ~32 kDa |
Purity : | >90% by densitometry |
Applications : | Western Blot |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 μg/μl |
Gene Name : | UBE2R2 ubiquitin-conjugating enzyme E2R 2 [ Homo sapiens ] |
Official Symbol : | UBE2R2 |
Synonyms : | UBE2R2; ubiquitin-conjugating enzyme E2R 2; ubiquitin-conjugating enzyme E2 R2; CDC34B; FLJ20419; MGC10481; UBC3B; ubiquitin-protein ligase R2; ubiquitin carrier protein R2; ubiquitin-conjugating enzyme UBC3B; ubiquitin-conjugating enzyme E2-CDC34B; E2-CDC34B; |
Gene ID : | 54926 |
mRNA Refseq : | NM_017811 |
Protein Refseq : | NP_060281 |
MIM : | 612506 |
UniProt ID : | Q712K3 |
Chromosome Location : | 9p11.2 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; |
Function : | ATP binding; acid-amino acid ligase activity; ligase activity; nucleotide binding; ubiquitin-protein ligase activity; |
Products Types
◆ Recombinant Protein | ||
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UBE2R2-9837M | Recombinant Mouse UBE2R2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ube2r2-6797M | Recombinant Mouse Ube2r2 Protein, Myc/DDK-tagged | +Inquiry |
UBE2R2-0043H | Recombinant Human UBE2R2 Protein (A2-S238), His/Strep tagged | +Inquiry |
UBE2R2-17731M | Recombinant Mouse UBE2R2 Protein | +Inquiry |
◆ Lysates | ||
UBE2R2-563HCL | Recombinant Human UBE2R2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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