Recombinant Human UMOD Protein (Glu334-Ser589), His tagged

• Cat.No.: UMOD-6542H
• Product Overview: Recombinant human UMOD (Glu334-Ser589) fused with His tag was expressed in E. coli.

Specification

• Description: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.
  Uromodulin, secreted form: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 29.71 kDa
• Protein Length: Glu334-Ser589
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: UMOD uromodulin [ Homo sapiens (human) ]
• Official Symbol: UMOD
• Synonyms: UMOD; uromodulin; uromodulin (uromucoid, Tamm Horsfall glycoprotein); Tamm Horsfall glycoprotein; uromucoid; Tamm-Horsfall glycoprotein; tamm-Horsfall urinary glycoprotein; uromodulin (uromucoid, Tamm-Horsfall glycoprotein); THP; FJHN; HNFJ; THGP; HNFJ1; MCKD2; ADMCKD2
• Gene ID: 7369
• mRNA Refseq: NM_001008389
• Protein Refseq: NP_001008390
• MIM: 191845
• UniProt ID: P07911