| Description : |
This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
103.6 kDa |
| AA Sequence : |
MAEVEAVQLKEEGNRHFQLQDYKAA TNSYSQALKLTKDKALLATLYRNRA ACGLKTESYIQAASDASRAIDINSS DIKALYRRCQALEHLGKLDQAFKDV QRCATLEPRNQNFQEMLRRLNTSIQ EKLRVQFSTDSRVQKMFEILLDENS EADKREKAANNLIVLGREEAGAEKI FQNNGVALLLQLLDTKKPELVLAAV RTLSGMCSGHQARATVILHAVRIDR ICSLMAVENEEMSLAVCNLLQAIID SLSGEDKREHRGKEEALVLDTKKDL KQITSHLLDMLVSKKVSGQGRDQAL NLLNKNVPRKDLAIHDNSRTIYVVD NGLRKILKVVGQVPDLPSCLPLTDN TRMLASILINKLYDDLRCDPERDHF RKICEEYITGKFDPQDMDKNLNAIQ TVSGILQGPFDLGNQLLGLKGVMEM MVALCGSERETDQLVAVEALIHAST KLSRATFIITNGVSLLKQIYKTTKN EKIKIRTLVGLCKLGSAGGTDYGLR QFAEGSTEKLAKQCRKWLCNMSIDT RTRRWAVEGLAYLTLDADVKDDFVQ DVPALQAMFELAKXXTSDKTILYSV ATTLVNCTNSYDVKEVIPELVQLAK FSKQHVPEEHPKDKKDFIDMRVKRL LKAGVISALACMVKADSAILTDQTK ELLARVFLALCDNPKDRGTIVAQGG GKALIPLALEGTDVGKVKAAHALAK IAAVSNPDIAFPGERVYEVVRPLVR LLDTQRDGLQNYEALLGLTNLSGRS DKLRQKIFKERALPDIENYMFENHD QLRQAATECMCNMVLHKEVQERFLA DGNDRLKLVVLLCGEDDDKVQNAAA GALAMLTAAHKKLCLKMTQVTTQWL EILQRLCLHDQLSVQHRGLVIAYNL LAADAELAKKLVESELLEILTVVGK QEPDEKKAEVVQTARECLIKCMDYG FIKPVSTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
