Recombinant Human USP19 Protein (E904-R1318), His tagged

• Cat.No.: USP19-0385H
• Product Overview: Recombinant Human 6His-TEV-GG-USP19(E904-R1318 end) Protein was expressed in E. coli.

Specification

• Description: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: E904-R1318
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: USP19 ubiquitin specific peptidase 19 [ Homo sapiens (human) ]
• Official Symbol: USP19
• Synonyms: USP19; ubiquitin specific peptidase 19; ubiquitin specific protease 19; ubiquitin carboxyl-terminal hydrolase 19; KIAA0891; ZMYND9; ubiquitin thioesterase 19; deubiquitinating enzyme 19; ubiquitin thiolesterase 19; ubiquitin-specific-processing protease 19; zinc finger MYND domain-containing protein 9
• Gene ID: 10869
• mRNA Refseq: NM_001199160
• Protein Refseq: NP_001186089
• MIM: 614471
• UniProt ID: O94966