Recombinant Human USP30 Protein (T57-E517), His tagged

• Cat.No.: USP30-0372H
• Product Overview: Recombinant Human 8His-TEV-GG-USP30(T57-E517 end) Protein was expressed in Insect cell.

Specification

• Description: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: T57-E517
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: USP30 ubiquitin specific peptidase 30 [ Homo sapiens (human) ]
• Official Symbol: USP30
• Synonyms: USP30; ubiquitin specific peptidase 30; ubiquitin specific protease 30; ubiquitin carboxyl-terminal hydrolase 30; FLJ40511; MGC10702; ub-specific protease 30; ubiquitin thioesterase 30; deubiquitinating enzyme 30; ubiquitin thiolesterase 30; ubiquitin-specific protease 30; ubiquitin-specific-processing protease 30
• Gene ID: 84749
• mRNA Refseq: NM_032663
• Protein Refseq: NP_116052
• MIM: 612492
• UniProt ID: Q70CQ3