Recombinant Human USP47 Protein (V2-D1375), Flag tagged

• Cat.No.: USP47-1342S
• Product Overview: Recombinant Human USP47(V2-D1375 end)-Flag Protein was expressed in Insect cell.

Specification

• Description: Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.
• Source: Insect cell
• Species: Human
• Tag: Flag
• Form: Liquid
• Protein length: V2-D1375
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: USP47 ubiquitin specific peptidase 47 [ Homo sapiens (human) ]
• Official Symbol: USP47
• Synonyms: USP47; ubiquitin specific peptidase 47; Trf (TATA binding protein related factor) proximal homolog (Drosophila), ubiquitin specific protease 47; ubiquitin carboxyl-terminal hydrolase 47; ubiquitin thioesterase 47; deubiquitinating enzyme 47; ubiquitin thiolesterase 47; ubiquitin specific protease 47; ubiquitin-specific-processing protease 47; Trf (TATA binding protein-related factor)-proximal homolog; TRFP; FLJ20727; DKFZp686C13257
• Gene ID: 55031
• mRNA Refseq: NM_017944
• Protein Refseq: NP_060414
• MIM: 614460
• UniProt ID: Q96K76

Reviews

07/28/2020

the USP47 protein stands out for its excellent quality, exceptional technical support, and wide range of applications.

05/09/2017

This protein has become an invaluable asset in my research, offering great versatility in its applications.

04/07/2016

Its robust performance has significantly accelerated my research progress and contributed to the advancement of my scientific understanding.

Q&As

How does USP47 protein contribute to drug resistance in cancer?

USP47 has been implicated in promoting drug resistance in cancer cells through its regulatory effects on cellular pathways involved in drug response.

Can USP47 protein be used as a prognostic marker for patient outcomes in cancer?

Studies have suggested that USP47 expression levels may correlate with patient prognosis, making it a potential prognostic marker in cancer.

Can the expression of USP47 protein be used to predict treatment response in cancer patients?

Studies have suggested that USP47 expression levels may correlate with treatment response in certain cancer types, highlighting its potential as a predictive biomarker.

What are the current strategies for developing USP47-targeted therapies for clinical use?

Current strategies include the identification of small molecule inhibitors and the development of targeted drug delivery systems to enhance the clinical applicability of USP47-targeted therapies.

Are there any diagnostic applications for USP47 protein in cancer detection?

USP47 expression levels could serve as a biomarker for certain types of cancer, aiding in early detection and prognosis.