| Description : |
This gene encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
76.9 kDa |
| AA Sequence : |
MGEFKVHRVRFFNYVPSGIRCVAYN NQSNRLAVSRTDGTVEIYNLSANYF QEKFFPGHESRATEALCWAEGQRLF SAGLNGEIMEYDLQALNIKYAMDAF GGPIWSMAASPSGSQLLVGCEDGSV KLFQITPDKIQFERNFDRQKSRILS LSWHPSGTHIAAGSIDYISVFDVKS GSAVHKMIVDRQYMGVSKRKCIVWG VAFLSDGTIISVDSAGKVQFWDSAT GTLVKSHLIANADVQSIAVADQEDS FVVGTAEGTVFHFQLVPVTSNSSEK QWVRTKPFQHHTHDVRTVAHSPTAL ISGGTDTHLVFRPLMEKVEVKNYDA ALRKITFPHRCLISCSKKRQLLLFQ FAHHLELWRLGSTVATGKNGDTLPL SKNADHLLHLKTKGPENIICSCISP CGSWIAYSTVSRFFLYRLNYEHDNI SLKRVSKMPAFLRSALQILFSEDST KLFVASNQGALHIVQLSGGSFKHLH AFQPQSGTVEAMCLLAVSPDGNWLA ASGTSAGVHVYNVKQLKLHCTVPAY NFPVTAMAIAPNTNNLVIAHSDQQV FEYSIPDKQYTDWSRTVQKQGFHHL WLQRDTPITHISFHPKRPMHILLHD AYMFCIIDKSLPLPNDKTLLYNPFP PTNESDVIRRRTAHAFKISKIYKPL LFMDLLDERTLVAVERPLDDIIAQL PPPIKKKKFGTTRTRPLEQKLISEE DLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
