Recombinant Human Vascular Cell Adhesion Molecule 1, His-tagged

• Cat.No.: VCAM1-6796H
• Product Overview: Recombinant humanVCAM1 protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: VCAM1 is a member ofthe Ig superfamily and is a cell surface sialoglycoprotein expressed bycytokine-activated endothelium. This type I membrane protein mediatesleukocyte-endothelial cell adhesion and signal transduction, and may play arole in the development of artherosclerosis and rheumatoid arthritis
• Form: Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 10% glycerol
• Molecular Weight: 76 kDa (695aa)
• Purity: > 80% by SDS -PAGE
• Concentration: 0.25 mg/ml (determinedby Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MFKIETTPES RYLAQIGDSV SLTCSTTGCE SPFFSWRTQI DSPLNGKVTN EGTTSTLTMNPVSFGNEHSY LCTATCESRK LEKGIQVEIY SFPKDPEIHL SGPLEAGKPI TVKCSVADVY PFDRLEIDLLKGDHLMKSQE FLEDADRKSL ETKSLEVTFT PVIEDIGKVL VCRAKLHIDE MDSVPTVRQA VKELQVYISPKNTVISVNPS TKLQEGGSVT MTCSSEGLPA PEIFWSKKLD NGNLQHLSGN ATLTLIAMRM EDSGIYVCEGVNLIGKNRKE VELIVQEKPF TVEISPGPRI AAQIGDSVML TCSVMGCESP SFSWRTQIDS PLSGKVRSEGTNSTLTLSPV SFENEHSYLC TVTCGHKKLE KGIQVELYSF PRDPEIEMSG GLVNGSSVTV SCKVPSVYPLDRLEIELLKG ETILENIEFL EDTDMKSLEN KSLEMTFIPT IEDTGKALVC QAKLHIDDME FEPKQRQSTQTLYVNVAPRD TTVLVSPSSI LEEGSSVNMT CLSQGFPAPK ILWSRQLPNG ELQPLSENAT LTLISTKMEDSGVYLCEGIN QAGRSRKEVE LIIQVTPKDI KLTAFPSESV KEGDTVIISC TCGNVPETWI ILKKKAETGDTVLKSIDGAY TIRKAQLKDA GVYECESKNK VGSQLRSLTL DVQGRENNKD YFSPE
• Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Cell adhesion molecules (CAMs);Leukocyte transendothelial migration; Signaling in Immune system

Gene Information

• Gene Name: VCAM1 vascular cell adhesionmolecule 1 [ Homo sapiens ]
• Official Symbol: VCAM1
• Synonyms: VCAM1; CD106; MGC99561; INCAM-100;DKFZp779G2333; vascular cell adhesion molecule 1; CD106 antigen;OTTHUMP00000012650; OTTHUMP00000012651; L1CAM; V-CAM 1
• Gene ID: 7412
• mRNA Refseq: NM_001078
• Protein Refseq: NP_001069
• MIM: 192225
• UniProt ID: P19320
• Chromosome Location: 1p32-p31
• Function: integrin binding; protein binding