VCAM1

  • Official Full Name

    vascular cell adhesion molecule 1

  • Overview

    Human Vascular Cell Adhesion Molecule-1 is a 100 - 110 kDa, 715 amino acid type I transmembrane glycoprotein typically characterized by the presence of seven C2-type immunoglobulin domains. Its extracellular region is 674 aa in length, followed by a 22 aa transmembrane segment and a 19 aa cytoplasmic tail. In the extracellular region, there are multiple N-linked glycosylation sites, and each C2 domain is closed by a disulfide bridge. There is considerable interspecies VCAM-1 homology, with mouse and rat VCAM-1 showing approximately 75% aa identity to human VCAM-1. Notably, the short 19 aa cytoplasmic tail is absolutely conserved, mouse to human to rat. Cells expressing mouse VCAM-1 bind both mouse and human leukocytes, and this reflects their high degree of aa identity. A number of variants of VCAM-1 are known to occur, all of which are likely the result of alternate gene splicing. In particular, a human six Ig domain molecule is known, and in rabbits, an eight Ig domain form has been identified. There is also a three-C2 domain, 43 kDa GPI-linked form of VCAM-1. Although it binds known VCAM-1 ligands, its function is unclear. Cells known to express VCAM-1 include neurons, endothelial cells, smooth muscle cells, fibroblasts and macrophages.<br/>Soluble VCAM-1 has been identified in culture supernates, blood, and cerebrospinal fluid. In vitro, basal levels of VCAM-1 shedding by unstimulated NIH3T3 cells appear to partially require metalloproteinase activity, while PMA-induced shedding is dependent upon the proteolytic activity of TACE/ADAM17.<br/>Functionally, VCAM-1 binds to both 4 1 and 4 7 integrins. These integrins are expressed on a variety of cells, with VLA-4 found on all leukocytes with the exception of neutrophils. Because of this, VCAM-1/VCAM-1 ligand interactions are undoubtedly key events in the rate and timing of leukocyte extravasation. Other roles proposed for VCAM-1 include the regulation of osteoclastogenesis via a cell-to-cell contact mechanism and the induction of sickle cell adherence to vascular endothelial cells during hypoxemia.<br/>The Human sVCAM-1 Immunoassay is a 2 hour solid-phase ELISA designed to measure human sVCAM-1 in cell culture supernates, serum, and plasma. It contains CHO cell-expressed recombinant human sVCAM-1 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human sVCAM-1 showed linear curves that were parallel to the standard curves obtained using the kit standards. These results indicate that the Human sVCAM-1 immunoassay kit can be used to determine relative mass values for naturally occurring sVCAM-1.
  • Synonyms

    VCAM1; vascular cell adhesion molecule 1; INCAM-100; Vascular cell adhesion protein 1 precursor; CD-10^6 antigen; CD10^6; DKFZp779G2333; MGC99561; CD10^6 antigen; OTTHUMP00000012650; OTTHUMP00000012651; L1CAM; V-CAM 1; CD106; Vcam-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Dog
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rabbit
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus monkey
  • Zebrafish
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Yeast
  • Biotin
  • C
  • hFc
  • His
  • Fc
  • Fc Chimera
  • Fc|His
  • Avi
  • Flag
  • GST
  • hIgG1
  • HIgG1 Fc
  • hIgG4
  • His (Fc)
  • His|S
  • His|T7
  • SUMO
  • mFc
  • MIgG2a Fc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human VCAM1-1794M Active Recombinant Human VCAM1, HIgG1 Fc-tagged CHO Fc
Human VCAM1-191H Active Recombinant Human VCAM1 Protein HEK293 N/A
Human VCAM1-68H Active Recombinant Human VCAM1 Protein, His-tagged, Bioactivity Validated Insect Cell His 25-698aa
Human VCAM1-170H Active Recombinant Human VCAM1 protein, His-tagged Mammalian cells His
Human VCAM1-71HA Active Recombinant Human VCAM1 protein, Fc-tagged, APC labeled HEK293 Fc Met 1-Pro 697
Human VCAM1-1794MAF555 Active Recombinant Human VCAM1 Protein, hFc-tagged, Alexa Fluor 555 conjugated CHO hFc
Human VCAM1-1794MAF488 Active Recombinant Human VCAM1 Protein, hFc-tagged, Alexa Fluor 488 conjugated CHO hFc
Human VCAM1-2178H Active Recombinant Human VCAM1 protein, Fc-tagged HEK293 Fc Phe 25 - Glu 698
Human VCAM1-1794MAF647 Active Recombinant Human VCAM1 Protein, hFc-tagged, Alexa Fluor 647 conjugated CHO hFc
Human VCAM1-1794MF Active Recombinant Human VCAM1 Protein, hFc-tagged, FITC conjugated CHO hFc
Human VCAM1-2325H Active Recombinant Human VCAM1 protein, His-tagged HEK293 His Phe 25 - Pro 697
Human VCAM1-1695H Recombinant Human Vascular Cell Adhesion Molecule 1 Mammalian cells N/A
Human VCAM1-6796H Recombinant Human Vascular Cell Adhesion Molecule 1, His-tagged E.coli His
Human VCAM1-179H Recombinant Human VCAM1 protein, T7-tagged E.coli T7
Human VCAM1-71H Active Recombinant Human VCAM1, Fc tagged HEK293 Fc Met 1-Pro 697
Human VCAM1-3142H Recombinant Human VCAM1, His tagged Human Cell His
Human VCAM1-31199TH Recombinant Human VCAM1, His-tagged E.coli His
Human VCAM1-2439HCL Recombinant Human VCAM1 cell lysate Human Cell N/A
Human VCAM1-5262H Recombinant Human VCAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human VCAM1-117H Recombinant Human VCAM1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human VCAM1-71HAF555 Recombinant Human VCAM1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 911
Human VCAM1-71HP Recombinant Human VCAM1 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human VCAM1-5544H Recombinant Human VCAM1 protein, His-tagged Yeast His 25-698aa
Human VCAM1-1794MP Recombinant Human VCAM1 protein, HIgG1 Fc-tagged, R-PE labeled CHO HIgG1 Fc
Human VCAM1-1794MA Recombinant Human VCAM1 protein, HIgG1 Fc-tagged, APC labeled CHO HIgG1 Fc
Human VCAM1-1534H Recombinant Human VCAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human VCAM1-1543H Recombinant Human VCAM1 Protein (Phe25-Glu698), N-His tagged E.coli N-His Phe25-Glu698
Human VCAM1-1831H Recombinant Human VCAM1 protein, GST-tagged E.coli GST 341-739 aa
Human VCAM1-171H Recombinant Human VCAM1 Protein, His-tagged Human Cells His
Human VCAM1-172H Recombinant Human VCAM1 Protein, His-tagged Human Cells His
Human VCAM1-5158H Recombinant Human VCAM1 Protein (Met1-Glu698), C-His tagged Mammalian cells C-His Met1-Glu698
Human DMABT-H18424 Mouse Anti-VCAM1 Monoclonal Antibody Mouse Biotin
Human VCAM1-3371H Recombinant Human VCAM1 protein, His-tagged HEK293 His Gln109~Ser318
Human VCAM1-3649H Recombinant Human VCAM1 protein, His-SUMO-tagged E.coli His-SUMO 25-698aa
Human VCAM1-473H Recombinant Human VCAM1 Protein, His-tagged HEK293 His 739
Human VCAM1-1473HFL Recombinant Full Length Human VCAM1 Protein, C-Flag-tagged Mammalian cells Flag
Human VCAM1-1364H Recombinant Human VCAM1 protein(Met 1-Pro 697), hFc-tagged, Biotinylated HEK293 C-hFc Met 1-Pro 697
Human VCAM1-71HAF488 Recombinant Human VCAM1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 911
Human VCAM1-2336H Recombinant Human VCAM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human VCAM1-71HF Recombinant Human VCAM1 Protein, Fc-tagged, FITC conjugated HEK293 Fc 911
Human VCAM1-0816H Active Recombinant Human VCAM1 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Phe25-Glu698
Human VCAM1-71HAF647 Recombinant Human VCAM1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 911
Human VCAM1-01H Active Recombinant Human VCAM1 Protein CHO
Human VCAM1-2336H-B Recombinant Human VCAM1 Protein Pre-coupled Magnetic Beads HEK293
Mouse VCAM1-1793M Active Recombinant Mouse VCAM1, MIgG2a Fc-tagged CHO Fc
Mouse Vcam1-1784M Active Recombinant Mouse Vcam1, His & hFc-tagged HEK293 His & hFc Met 1-Glu 698
Mouse Vcam1-4013M Active Recombinant Mouse Vcam1, His-tagged Mouse His
Mouse Vcam1-491M Active Recombinant Mouse Vcam1, Fc Chimera Mammalian cells Fc Chimera
Mouse VCAM1-1793MF Active Recombinant Mouse VCAM1 Protein, MIgG2a mFc-tagged, FITC conjugated CHO mFc
Mouse VCAM1-1793MAF488 Active Recombinant Mouse VCAM1 Protein, MIgG2a mFc-tagged, Alexa Fluor 488 conjugated CHO mFc
Mouse VCAM1-1793MAF647 Active Recombinant Mouse VCAM1 Protein, MIgG2a mFc-tagged, Alexa Fluor 647 conjugated CHO mFc
Mouse VCAM1-1793MAF555 Active Recombinant Mouse VCAM1 Protein, MIgG2a mFc-tagged, Alexa Fluor 555 conjugated CHO mFc
Mouse Vcam1-2771M Recombinant Mouse Vcam1 protein, His-tagged E.coli His Pro116~Gln309 (Accession # P29533)
Mouse Vcam1-188M Recombinant Mouse Vcam1 protein, His-tagged Insect Cell His
Mouse Vcam1-2313M Recombinant Mouse Vcam1, Fc-His tagged Human Cell Fc/His
Mouse Vcam1-4012M Active Recombinant Mouse Vcam1 protein, His-tagged HEK293 His Met1-Glu698
Mouse Vcam1-2772M Recombinant Mouse Vcam1 protein, His-tagged E.coli His Pro511~Thr682 (Accession # P29533)
Mouse VCAM1-2094MCL Recombinant Mouse VCAM1 cell lysate Human Cell N/A
Mouse VCAM1-2653MCL Recombinant Mouse VCAM1 cell lysate Human Cell N/A
Mouse VCAM1-1793MP Recombinant Mouse VCAM1 protein, MIgG2a Fc-tagged, R-PE labeled CHO MIgG2a Fc
Mouse Vcam1-2313MP Recombinant Mouse Vcam1 protein, Fc-His-tagged, R-PE labeled HEK293 Fc/His
Mouse Vcam1-6909M Recombinant Mouse Vcam1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Vcam1-492M Recombinant Mouse Vcam1 Protein, Fc-tagged HEK293 Fc Phe25-Glu698
Mouse Vcam1-2313MAF647 Recombinant Mouse Vcam1 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 922
Mouse Vcam1-2313MAF555 Recombinant Mouse Vcam1 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 922
Mouse Vcam1-10627M-B Recombinant Mouse Vcam1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Vcam1-7363M Recombinant Mouse Vcam1 Protein, His-tagged Insect Cell His 25-698
Mouse Vcam1-2313MF Recombinant Mouse Vcam1 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 922
Mouse Vcam1-2313MA Recombinant Mouse Vcam1 protein, Fc-His-tagged, APC labeled HEK293 Fc/His
Mouse Vcam1-2313MAF488 Recombinant Mouse Vcam1 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 922
Mouse Vcam1-550M Recombinant Mouse Vcam1 Protein, His-tagged E.coli N-His Q+Val110-Ser318
Mouse VCAM1-1793MA Recombinant Mouse VCAM1 protein, MIgG2a Fc-tagged, APC labeled CHO MIgG2a Fc
Mouse Vcam1-10627M Recombinant Mouse Vcam1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat VCAM1-6505R Recombinant Rat VCAM1 Protein Mammalian Cell His
Rat Vcam1-2773R Recombinant Rat Vcam1 protein, His & T7-tagged E.coli His/T7 Thr369~Ala658 (Accession # P29534)
Rat Vcam1-551R Recombinant Rat Vcam1 Protein, His-tagged E.coli N-His Ala20-Thr682
Rat VCAM1-6161R-B Recombinant Rat VCAM1 Protein Pre-coupled Magnetic Beads HEK293
Rat Vcam1-3650R Recombinant Rat Vcam1 protein, His-tagged E.coli His 31-697aa
Rat VCAM1-6161R Recombinant Rat VCAM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey VCAM1-2775R Recombinant Rhesus monkey VCAM1 protein, His & T7-tagged E.coli His/T7 Leu1~Asp81
Rhesus monkey VCAM1-1534R Recombinant Rhesus Monkey VCAM1 Protein HEK293 N/A
Rhesus monkey VCAM1-1535R Recombinant Rhesus Monkey VCAM1 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey VCAM1-1536R Recombinant Rhesus Monkey VCAM1 Protein, hIgG4-tagged HEK293 hIgG4
Rabbit VCAM1-2774R Recombinant Rabbit VCAM1 protein, His & S-tagged E.coli His/S Ile409~Thr682 (Accession # Q865F2)
Dog VCAM1-2770D Recombinant Dog VCAM1 protein, His-tagged E.coli His Thr136~Pro372
Mus musculus (Mouse) RFL14613MF Recombinant Full Length Mouse Vascular Cell Adhesion Protein 1(Vcam1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-739)
Rattus norvegicus (Rat) RFL3791RF Recombinant Full Length Rat Vascular Cell Adhesion Protein 1(Vcam1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-739)
Zebrafish VCAM1-5452Z Recombinant Zebrafish VCAM1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

VCAM1 involved in several pathways and played different roles in them. We selected most pathways VCAM1 participated on our site, such as NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with VCAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayNFKBIA;PLAU;TNFSF11;RIPK1;PRKCB;TRAF3;PTGS2;GM10591;IKBKB
Cell adhesion molecules (CAMs)H2-AA;NLGN3;HLA-DRA;CADM3;L1CAM;ITGAL;PVRL1B;NFASC;CD6
TNF signaling pathwayIL18R1;MAPK3;CREB3L1;ICAM1;PTGS2;FOS;CCL2;MAP3K7IP3;CXCL10
Leukocyte transendothelial migrationEZR;CXCL12;PECAM1;VAV3;MAPK13;CLDN10;RAC2;THY1;VCL
African trypanosomiasisVCAM1;F2RL1;IL6;FAS;HBB;IL1B;Fasl;MYD88;PLCB1
MalariaHBA1;TGFB2;HBB-B2;CD40LG;CD36;ICAM1;HBA-A2;HBB;COMP
HTLV-I infectionRANBP1;HLA-DRB5;NFATC4;MAP3K14;PIK3R2;H2-Q10;SRF;ETS1;HLA-B

VCAM1 has several biochemical functions, for example, cell adhesion molecule binding, integrin binding, primary amine oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VCAM1 itself. We selected most functions VCAM1 had, and list some proteins which have the same functions with VCAM1. You can find most of the proteins on our site.

Function Related Protein
cell adhesion molecule bindingCAML;PTBP3;CADM3;NRXN1;Fert2;ITGA4;PKP3;CD226;DSG2
integrin bindingADAM10;ICAM2;COL4A3;FBLN1;VWF;WISP1B;ADAMTS8;ADAMTS5;GFAP
primary amine oxidase activityMAOA;VCAM1;ABP1;AOC2;AOC3;AOC1;MAOB

VCAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VCAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of VCAM1.

ITGB1; ZYX; TLN1; PSMD11

Research Area

Related articles

Almeda, D; Wang, BR; et al. Minimizing antibody surface density on liposomes while sustaining cytokine-activated EC targeting. BIOMATERIALS 41:37-44(2015).
Marschall, AL; Single, FN; et al. Functional knock down of VCAM1 in mice mediated by endoplasmatic reticulum retained intrabodies. MABS 6:1394-1401(2014).
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