Recombinant Human VHL, His-tagged

• Cat.No.: VHL-28605TH
• Product Overview: Recombinant full length human Von Hippel Lindau protein with His tag expressed in a baculovirus system; 213 amino acids, 24kDa.

Specification

• Species: Human
• Tag: His
• Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
• Conjugation: HIS
• Tissue specificity: Expressed in the adult and fetal brain and kidney.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Full Length: Full L.

Gene Information

• Gene Name: VHL von Hippel-Lindau tumor suppressor [ Homo sapiens ]
• Official Symbol: VHL
• Synonyms: VHL; von Hippel-Lindau tumor suppressor; von Hippel Lindau syndrome; von Hippel-Lindau disease tumor suppressor; VHL1
• Gene ID: 7428
• mRNA Refseq: NM_000551
• Protein Refseq: NP_000542
• MIM: 608537
• Uniprot ID: P40337
• Chromosome Location: 3p25.3
• Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem
• Function: protein binding; transcription factor binding