Recombinant Human VHLL Protein, His-tagged

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Recombinant Human VHLL Protein, His-tagged

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Cat.No. : VHLL-369H
Product Overview : Recombinant human VHLL protein, fused to His tag at N-terminus, was expressed in E. coli.
Description : Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha. [provided by RefSeq, Jan 2010].
Source : E. coli
Species : Human
Tag : His
Form : 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
Molecular Mass : 15.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : VHL like [ Homo sapiens ]
Official Symbol : VHLL
Synonyms : VHLP; VLP
Gene ID : 391104
mRNA Refseq : NM_001004319.2
Protein Refseq : NP_001004319.1
UniProt ID : Q6RSH7

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