Recombinant Human VTCN1 protein, Fc-tagged, low endotoxin
Cat.No. : | VTCN1-572H |
Product Overview : | Recombinant Human VTCN1 (Phe29-Ala258) protein (low endotoxin) was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293). |
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Description : | V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1/B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation. |
Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Predicted N Terminal : | Phe29 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 51.8 kDa. The protein migrates as 66-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Phe29-Ala258 |
Endotoxin : | Less than 0.01 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | VTCN1 |
Official Symbol : | VTCN1 |
Synonyms : | VTCN1; V-set domain containing T cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; B7 family member; H4; B7 superfamily member 1; B7 H4; B7H4; B7S1; B7X; FLJ22418; B7 family member, H4; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; immune costimulatory protein B7-H4; B7-H4; B7h.5; VCTN1; PRO1291; RP11-229A19.4 |
Gene ID : | 79679 |
mRNA Refseq : | NM_001253849 |
Protein Refseq : | NP_001240778 |
MIM : | 608162 |
UniProt ID : | Q7Z7D3 |
Products Types
◆ Recombinant Protein | ||
VTCN1-787M | Recombinant Mouse VTCN1 Protein (Phe29-Ser256), His-tagged | +Inquiry |
VTCN1-429H | Active Recombinant Human VTCN1 Protein, His-tagged, Biotinylated | +Inquiry |
Vtcn1-152M | Recombinant Mouse Vtcn1 Protein, His (Fc)-Avi-tagged | +Inquiry |
VTCN1-7298H | Recombinant Human VTCN1 protein, hFc-tagged | +Inquiry |
VTCN1-1519R | Active Recombinant Rhesus macaque VTCN1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
VTCN1-1096HCL | Recombinant Human VTCN1 cell lysate | +Inquiry |
VTCN1-1636MCL | Recombinant Mouse VTCN1 cell lysate | +Inquiry |
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Not For Human Consumption!
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