Recombinant Human WASHC1 Protein, MYC/DDK-tagged, C13 and N15-labeled

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Recombinant Human WASHC1 Protein, MYC/DDK-tagged, C13 and N15-labeled

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Cat.No. : WASHC1-148H
Product Overview : WASH1 MS Standard C13 and N15-labeled recombinant protein (NP_878908) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity). Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling. Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 50.1 kDa
AA Sequence : MTPVRMQHSL AGQTYAVPFI QPDLRREEAV QQMADALQYL QKVSGDIFSR ISQQVEQSRS QVQAIGEKVS LAQAKIEKIK GSKKAIKVFS SAKYPAPGRL QEYGSIFTGA QDPGLQRRPR HRIQSKHRPL DERALQEKLK DFPVCVSTKP EPEDDAEEGL GGLPSNISSV SSLLLFNTTE NLYKKYVFLD PLAGAVTKTH VMLGAETEEK LFDAPLSISK REQLEQQVPE NYFYVPDLGQ VPEIHVPSYL PDLPGIANDL MYSADLGPGI APSAPGTIPE LPTFHTEVAE PLKVDLQDGV LTPPPPPPPP PPAPEVLASA PPLPPSTAAP VGQGARQDDS SSSASPSVQG APREVVDPSG GWATLLESIR QAGGIGKAKL RSMKERKLEK QQQKEQEQVR ATSQGGHLMS DLFNKLVMRR KGISGKGPGA GEGPGGAFVR VSDSIPPLPP PQQPQAEEDE DDWESTRTRP LEQKLISEED LAANDILDYK DDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : WASHC1 WASH complex subunit 1 [ Homo sapiens (human) ]
Official Symbol : WASHC1
Synonyms : WASHC1; WASH complex subunit 1; FAM39E; WASH; WASH1; WASH complex subunit 1; CXYorf1-like protein on chromosome 9; FLJ00075 protein; WAS protein family homolog 1; actin nucleation promoting factor; family with sequence similarity 39, member E
Gene ID : 100287171
mRNA Refseq : NM_182905
Protein Refseq : NP_878908
MIM : 613632
UniProt ID : A8K0Z3

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