"WHSC1" Related Products

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Recombinant Human WHSC1 protein, GST-tagged, Active

Cat.No.: WHSC1-201H
Product Overview: Recombinant Human WHSC1(911-end) fused with GST tag at N-terminal was expressed in Insect cells.
Description: Histone-lysine N-methyltransferase NSD2 or Multiple myeloma SET domain-containing protein (MMSET) is a histone methyltransferase (HMT) with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Overexpressed in t(4;14)+ multiple myeloma (MM) patients, leading to an increase in histone 3 lysine 36 dimethylation (H3K36me2), and a decrease in histone 3 lysine 27 trimethylation (H3K27me3), accompanied by changes in proliferation, gene expression and chromatin accessibility.
Source: Insect cells
Species: Human
Tag : GST
Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 350 nmol/min/mg
Molecular Mass: 80 kDa
Purity: >70%
Applications: Methyltransferase Assay
Stability: 1 year at -70 centigrade from the date of shipment
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: WHSC1 Wolf-Hirschhorn syndrome candidate 1 [ Homo sapiens ]
Official Symbol: WHSC1
Synonyms: WHSC1; Wolf-Hirschhorn syndrome candidate 1; probable histone-lysine N-methyltransferase NSD2; MMSET; NSD2; trithorax/ash1-related protein 5; nuclear SET domain-containing protein 2; IL5 promoter REII region-binding protein; multiple myeloma SET domain co
Gene ID: 7468
mRNA Refseq: NM_133330
Protein Refseq: NP_579877
MIM: 602952
UniProt ID: O96028
Chromosome Location: 4p16.3
Pathway: Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem;
Function: DNA binding; histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; transferase activity; zinc ion binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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