| Description : |
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
134.6 kDa |
| AA Sequence : |
MLASPATETTVLMSQTEADLALRPP PPLGTAGQPRLGPPPRRARRFSGKA EPRPRSSRLSRRSSVDLGLLSSWSL PASPAPDPPDPPDSAGPGPARSPPP SSKEPPEGTWTEGAPVKAAEDSARP ELPDSAVGPGSREPLRVPEAVALER RREQEEKEDMETQAVATSPDGRYLK FDIEIGRGSFKTVYRGLDTDTTVEV AWCELQTRKLSRAERQRFSEEVEML KGLQHPNIVRFYDSWKSVLRGQVCI VLVTELMTSGTLKTYLRRFREMKPR VLQRWSRQILRGLHFLHSRVPPILH RDLKCDNVFITGPTGSVKIGDLGLA TLKRASFAKSVIGTPEFMAPEMYEE KYDEAVDVYAFGMCMLEMATSEYPY SECQNAAQIYRKVTSGRKPNSFHKV KIPEVKEIIEGCIRTDKNERFTIQD LLAHAFFREERGVHVELAEEDDGEK PGLKLWLRMEDARRGGRPRDNQAIE FLFQLGRDAAEEVAQEMVALGLVCE ADYQPVARAVRERVAAIQRKREKLR KARELEALPPEPGPPPATVPMAPGP PSVFPPEPEEPEADQHQPFLFRHAS YSSTTSDCETDGYLSSSGFLDASDP ALQPPGGVPSSLAESHLCLPSAFAL SIPRSGPGSDFSPGDSYASDAASGL SDVGEGMGQMRRPPGRNLRRRPRSR LRVTSVSDQNDRVVECQLQTHNSKM VTFRFDLDGDSPEEIAAAMVYNEFI LPSERDGFLRRIREIIQRVETLLKR DTGPMEAAEDTLSPQEEPAPLPALP VPLPDPSNEELQSSTSLEHRSWTAF STSSSSPGTPLSPGNPFSPGTPISP GPIFPITSPPCHPSPSPFSPISSQV SSNPSPHPTSSPLPFSSSTPEFPVP LSQCPWSSLPTTSPPTFSPTCSQVT LSSPFFPPCPSTSSFPSTTAAPLLS LASAFSLAVMTVAQSLLSPSPGLLS QSPPAPPSPLPSLPLPPPVAPGGQE SPSPHTAEVESEASPPPARPLPGEA RLAPISEEGKPQLVGRFQVTSSKEP AEPLPLQPTSPTLSGSPKPSTPQLT SESSDTEDSAGGGPETREALAESDR AAEGLGAGVEEEGDDGKEPQVGGSP QPLSHPSPVWMNYSYSSLCLSSEES ESSGEDEEFWAELQSLRQKHLSEVE TLQTLQKKEIEDLYSRLGKQPPPGI VAPAAMLSSRQRRLSKGSFPTSRRN SLQRSEPPGPGIMRRNSLSGSSTGS QEQRASKGVTFAGDVGRMSGPTRTR RLEQKLISEEDLAANDILDYKDDDD KV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
