Recombinant Human?WNT5A?Full Length Protein, His-tagged

• Cat.No.: WNT5A-2474H
• Product Overview: Recombinant Human WNT5A Protein (62-380 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Cancer. Protein Description: Full Length of Mature Protein.

Specification

• Description: Alternative name(s): G1 to S phase transition protein 1 homolog ERF3A.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 37.8 kDa
• Protein length: 62-380 a.a.
• AA Sequence: IIGAQPLCSQLAGLSQGQKKLCHLY QDHMQYIGEGAKTGIKECQYQFRHR RWNCSTVDNTSVFGRVMQIGSRETA FTYAVSAAGVVNAMSRACREGELST CGCSRAARPKDLPRDWLWGGCGDNI DYGYRFAKEFVDARERERIHAKGSY ESARILMNLHNNEAGRRTVYNLADV ACKCHGVSGSCSLKTCWLQLADFRK VGDALKEKYDSAAAMRLNSRGKLVQ VNSRFNSPTTQDLVYIDPSPDYCVR NESTGSLGTQGRLCNKTSEGMDGCE LMCCGRGYDQFKTVQTERCHCKFHW CCYVKCKKCTEIVDQFVCK
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: WNT5A wingless-type MMTV integration site family, member 5A [ Homo sapiens ]
• Official Symbol: WNT5A
• Synonyms: WNT5A; protein Wnt-5a; hWNT5A; WNT 5A protein; WNT-5A protein
• Gene ID: 7474
• mRNA Refseq: NM_001256105
• Protein Refseq: NP_001243034
• MIM: 164975
• UniProt ID: P41221

Reviews

11/14/2019

Satisfied with performance, quality.

08/27/2019

Great product, satisfied customer.

02/27/2019

High purity, works well.

Q&As

What role does WNT5A play in cancer biology?

Its role in cancer is complex, acting as a tumor suppressor or promoter depending on context.

How does WNT5A interact with its receptors to initiate signal transduction?

It binds to Frizzled receptors and co-receptors, activating non-canonical Wnt signaling pathways.

In which developmental processes is WNT5A critically involved?

WNT5A is involved in embryonic development, particularly in limb formation and organogenesis.

How is WNT5A implicated in immune system regulation?

WNT5A modulates various immune responses, influencing inflammation and cell migration.

What is the primary role of WNT5A in cellular processes?

WNT5A is crucial in regulating cell proliferation, migration, and differentiation.

What therapeutic strategies are being explored involving WNT5A modulation?

Strategies include developing WNT5A modulators for potential use in cancer therapy and regenerative medicine.

Are there known genetic mutations in WNT5A associated with specific diseases?

Genetic mutations and altered expression of WNT5A are linked to developmental disorders and cancer.