Recombinant Human ZKSCAN3 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ZKSCAN3-1789H
• Product Overview: ZKSCAN3 MS Standard C13 and N15-labeled recombinant protein (NP_077819) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.
• Molecular Mass: 60.6 kDa
• AA Sequence: MARELSESTALDAQSTEDQMELLVIKVEEEEAGFPSSPDLGSEGSRERFRGFRYPEAAGPREALSRLRELCRQWLQPEMHSKEQILELLVLEQFLTILPGNLQSWVREQHPESGEEVVVLLEYLERQLDEPAPQVSGVDQGQELLCCKMALLTPAPGSQSSQFQLMKALLKHESVGSQPLQDRVLQVPMLAHGGCCREDAVVASRLTPESQGLLKVEDVALTLTPEWTQQDSSQGNLCRDEKQENHGSLVSLGDEKQTKSRDLPPAEELPEKEHGKISCHLREDIAQIPTCAEAGEQEGRLQRKQKNATGGRRHICHECGKSFAQSSGLSKHRRIHTGEKPYECEECGKAFIGSSALVIHQRVHTGEKPYECEECGKAFSHSSDLIKHQRTHTGEKPYECDDCGKTFSQSCSLLEHHRIHTGEKPYQCSMCGKAFRRSSHLLRHQRIHTGDKNVQEPEQGEAWKSRMESQLENVETPMSYKCNECERSFTQNTGLIEHQKIHTGEKPYQCNACGKGFTRISYLVQHQRSHVGKNILSQTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ZKSCAN3 zinc finger with KRAB and SCAN domains 3 [ Homo sapiens (human) ]
• Official Symbol: ZKSCAN3
• Synonyms: ZKSCAN3; zinc finger with KRAB and SCAN domains 3; zinc finger protein 306, zinc finger protein 309, ZNF306, ZNF309; zinc finger protein with KRAB and SCAN domains 3; dJ874C20.1; ZF47; Zfp47; zinc finger protein 306; zinc finger protein 309; zinc finger protein zfp47; zinc finger protein 47 homolog; zinc finger and SCAN domain-containing protein 13; ZFP306; ZNF306; ZNF309; zfp-47; ZSCAN13; dJ874C20.1.; FLJ33906; KIAA0426
• Gene ID: 80317
• mRNA Refseq: NM_024493
• Protein Refseq: NP_077819
• MIM: 612791
• UniProt ID: Q9BRR0