Recombinant Human ZNF207 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human ZNF207 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : ZNF207-2459H
Product Overview : ZNF207 MS Standard C13 and N15-labeled recombinant protein (NP_001091977) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 52.5 kDa
AA Sequence : MGRKKKKQLK PWCWYCNRDF DDEKILIQHQ KAKHFKCHIC HKKLYTGPGL AIHCMQVHKE TIDAVPNAIP GRTDIELEIY GMEGIPEKDM DERRRLLEQK TQESQKKKQQ DDSDEYDDDD SAASTSFQPQ PVQPQQGYIP PMAQPGLPPV PGAPGMPPGI PPLMPGVPPL MPGMPPVMPG MPPGLHHQRK YTQSFCGENI MMPMGGMMPP GPGIPPLMPG MPPGMPPPVP RPGIPPMTQA QAVSAPGILN RPPAPTATVP APQPPVTKPL FPSAGQMGTP VTSSSTASSN SESLSASSKA LFPSTAQAQA AVQGPVGTDF KPLNSTPATT TEPPKPTFPA YTQSTASTTS TTNSTAAKPA ASITSKPATL TTTSATSKLI HPDEDISLEE RRAQLPKYQR NLPRPGQAPI GNPPVGPIGG MMPPQPGIPQ QQGMRPPMPP HGQYGGHHQG MPGYLPGAMP PYGQGPPMVP PYQGGPPRPP MGMRPPVMSQ GGRYTRTRPL EQKLISEEDL AANDILDYKD DDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : ZNF207 zinc finger protein 207 [ Homo sapiens (human) ]
Official Symbol : ZNF207
Synonyms : ZNF207; zinc finger protein 207; DKFZp761N202;
Gene ID : 7756
mRNA Refseq : NM_001098507
Protein Refseq : NP_001091977
MIM : 603428
UniProt ID : O43670

Products Types

◆ Recombinant Protein

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◆ Lysates

ZNF207-122HCLRecombinant Human ZNF207 293 Cell Lysate+Inquiry

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