Recombinant Macaca mulatta Interleukin 6 (interferon, beta 2)

• Cat.No.: IL6-5433M
• Product Overview: Recombinant RhesusMacaque IL6 is a single non-glycosylated polypeptide chain containing 186amino acids.

Specification

• Cat. No.: IL6-5433M
• Description: IL6 is a pleiotropic cytokine that plays animportant role in host defense by regulating immune and inflammatoryresponses. Produced by T cells, monocytes, fibroblasts, endothelial cells andkeratinocytes, IL6 has diverse biological functions. It stimulates B-celldifferentiation and antibody production, synergizes with IL-3 inmegakaryocyte development and platelet production, induces expression ofhepatic acute-phase proteins, and regulates bone metabolism. IL6 signalsthrough the IL6 receptor system that consists of two chains, IL6Rα and gp130.
• Source: E. coli
• Species: Macaca mulatta
• Form: Lyophilized from a0.2 µm filtered concentrated solution in PBS, pH 7.4.
• MolecularWeight: 21.1 kDa
• Purity: > 97% by SDS-PAGEand HPLC analyses
• Endotoxin Level: < 0.1 ng/µg ofprotein
• Biological Activity: The ED50as determined by the dose-dependent stimulation of the proliferation ofIL-6-dependent mouse 7TD1 cells is < 0.1 ng/ml, corresponding to aspecific activity of >1×107 units/mg.
• Sequences: MAPVLPGEDSKNVAAPHSQP LTSSERIDKH IRYILDGISA LRKETCNRSN MCESSKEALA ENNLNLPKMA EKDGCFQSGFNEDTCLVKII TGLLEFEVYL EYLQNRFESS EEQARAVQMS TKVLIQFLQK KAKNLDAITT PEPTTNASLLTKLQAQNQWL QDMTTHLILR SFKEFLQSNL RALRQM
• Reconstitution: Centrifuge vialprior to opening to bring contents to the bottom. Reconstitute in steriledistilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml.Further dilutions should be made in appropriate buffered solutions.
• Storage: The lyophilizedproduct is stable for several weeks at 2-4°C, but should be stored desiccatedat -20°C. After reconstitution, the protein should be divided into workingaliquots and frozen at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: IL6
• Tag: Non

Gene Information

• Gene Name: IL6 interleukin 6 (interferon,beta 2) [ Macaca mulatta ]
• Synonyms: IL6; interleukin 6(interferon, beta 2); interleukin-6; IL-6
• Gene ID: 705819
• mRNA Refseq: NM_001042733
• Protein Refseq: NP_001036198
• UniProt ID: P51494
• Chromosome Location: 3
• Pathway: African trypanosomiasis; Amoebiasis;Cytokine-cytokine receptor interaction; Cytosolic DNA-sensing pathway;Graft-versus-host disease; HTLV-I infection; Hematopoietic cell lineage; Herpessimplex infection; Influenza A; Intestinal immune network for IgA production;Jak-STAT signaling pathway; Legionellosis; Malaria; NOD-like receptorsignaling pathway

Reviews

03/05/2022

Accurate localization and function within the cell.

01/31/2021

The binding affinity and affinity constant with the target are high.

03/12/2020

Can form a stable micellar structure.

Q&As

What is the dosage and usage of Il6?

The dosage and usage of Il6 will vary according to the disease, and generally require individualized regulation by the physician according to the disease situation.

What are the pharmacokinetic properties of Il6?

The pharmacokinetic characteristics of Il6 mainly include drug absorption, distribution, metabolism, excretion and other information.

Does Il6 have advantages in the treatment of multiple myeloma?

Recombinant Il6 protein has a unique therapeutic advantage in the treatment of multiple myeloma. It can promote the proliferation and differentiation of hematopoietic stem cells and inhibit the growth of tumor cells.

Does Il6 have specific therapeutic effects for certain diseases?

Il6 has specific therapeutic effects for certain diseases, such as rheumatoid arthritis, multiple myeloma and so on.

In which diseases is Il6 widely used?

This protein is widely used in the treatment of rheumatoid arthritis, pneumonia, multiple myeloma, lymphoma, malignant tumors and other diseases.

What is the effect of Il6 on immune cells?

The effects of Il6 on immune cells are mainly manifested as promoting cell proliferation and differentiation, regulating immune response, etc.