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Recombinant Monkey TNFRSF4 Protein, His-tagged, Alexa Fluor 555 conjugated

Cat.No. : TNFRSF4-548RAF555
Product Overview : Alexa Fluor 555 conjugated recombinant Rhesus TNFRSF4 (XP_001090870.1) (Met1-Ala216) was expressed with a polyhistidine tag at the C-terminus.
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Description : OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.
Source : HEK293
Species : Monkey
Tag : His
Form : Lyophilized
Molecular Mass : 21.7 kDa
Protein length : Met1-Ala216, 199
N-terminal Sequence Analysis : Leu 29
Endotoxin : < 1.0 EU/ μg protein as determined by the LAL method.
Purity : > 95 % as determined by SDS-PAGE
Characteristic : Disulfide-linked homodimer
Labeled with Alexa Fluor 555 via amines
With an excitation and emission maximum of 555/565 nm, Alexa Fluor 555 can be efficiently excited using a 543 nm He-Ne laser line and detected under standard TRITC/Cy3 filters.
Storage : Samples are stable for up to twelve months from date of receipt at -70 centigrade. Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.
Gene Name : TNFRSF4 TNF receptor superfamily member 4 [ Macaca mulatta (Rhesus monkey) ]
Official Symbol : TNFRSF4
Synonyms : TNFRSF4; TNF receptor superfamily member 4; tumor necrosis factor receptor superfamily member 4; tumor necrosis factor receptor superfamily, member 4
Gene ID : 699674
mRNA Refseq : XM_001090870
Protein Refseq : XP_001090870

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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