Recombinant Mouse a Protein, Myc/DDK-tagged

• Cat.No.: a-1445M
• Product Overview: Purified recombinant protein of mouse full-length nonagouti (a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth.
• Molecular Mass: 14.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: a nonagouti [ Mus musculus (house mouse) ]
• Official Symbol: a
• Synonyms: a; nonagout; As; ASP; ago; A; ASIP; agouti-signaling protein; agouti coat color protein; agouti signal protein; agouti switch protein; non-agouti
• Gene ID: 50518
• mRNA Refseq: NM_015770
• Protein Refseq: NP_056585
• UniProt ID: Q03288