Recombinant Mouse Adprhl2 Protein, MYC/DDK-tagged
Cat.No. : | Adprhl2-022M |
Product Overview : | Purified recombinant protein of full-length mouse ADP-ribosylhydrolase like 2 (Adprhl2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers. |
Source : | HEK293T |
Species : | Mouse |
Tag : | MYC/DDK |
Molecular Mass : | 39.9 kDa |
Purity : | >80%, as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Adprhl2 ADP-ribosylhydrolase like 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Adprhl2 |
Synonyms : | Adprhl2; ADP-ribosylhydrolase like 2; Arh3; Adprs; AI836109; ADP-ribose glycohydrolase ARH3; ADP-ribosylhydrolase 2; ADP-ribosylhydrolase 3; O-acetyl-ADP-ribose deacetylase ARH3; [Protein ADP-ribosylarginine] hydrolase-like protein 2; [Protein ADP-ribosylserine] hydrolase; ecto ADP-ribosylhydrolase; poly(ADP-ribose) glycohydrolase ARH3; EC 3.2.1.143 |
Gene ID : | 100206 |
mRNA Refseq : | NM_133883 |
Protein Refseq : | NP_598644 |
UniProt ID : | Q8CG72 |
Products Types
◆ Recombinant Protein | ||
ADPRHL2-361M | Recombinant Mouse ADPRHL2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Adprhl2-2066M | Recombinant Mouse ADP-ribosylhydrolase Like 2, His-tagged | +Inquiry |
ADPRHL2-2065H | Recombinant Human ADP-ribosylhydrolase Like 2, His-tagged | +Inquiry |
ADPRHL2-1288Z | Recombinant Zebrafish ADPRHL2 | +Inquiry |
ADPRHL2-9440H | Recombinant Human ADPRHL2, His-tagged | +Inquiry |
◆ Lysates | ||
ADPRHL2-9001HCL | Recombinant Human ADPRHL2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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