Recombinant Mouse Adprhl2 Protein, MYC/DDK-tagged Adprhl2-022M

Recombinant Mouse Adprhl2 Protein, MYC/DDK-tagged

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Recombinant Mouse Adprhl2 Protein, MYC/DDK-tagged

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Cat.No. : Adprhl2-022M
Product Overview : Purified recombinant protein of full-length mouse ADP-ribosylhydrolase like 2 (Adprhl2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 39.9 kDa
Purity : >80%, as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Adprhl2 ADP-ribosylhydrolase like 2 [ Mus musculus (house mouse) ]
Official Symbol : Adprhl2
Synonyms : Adprhl2; ADP-ribosylhydrolase like 2; Arh3; Adprs; AI836109; ADP-ribose glycohydrolase ARH3; ADP-ribosylhydrolase 2; ADP-ribosylhydrolase 3; O-acetyl-ADP-ribose deacetylase ARH3; [Protein ADP-ribosylarginine] hydrolase-like protein 2; [Protein ADP-ribosylserine] hydrolase; ecto ADP-ribosylhydrolase; poly(ADP-ribose) glycohydrolase ARH3; EC 3.2.1.143
Gene ID : 100206
mRNA Refseq : NM_133883
Protein Refseq : NP_598644
UniProt ID : Q8CG72

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