Recombinant Mouse Agrp protein, His-tagged
Cat.No. : | Agrp-6781M |
Product Overview : | Recombinant Mouse Agrp aa. (Val21~Thr131 (Accession # P56473)) fused with N-terminal His tag was produced in E. coli cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein that regulates feeding behavior and plays a key role in the control of body weight. The encoded protein acts as an antagonist of melanocortin receptor signaling. Alternatively spliced transcript variants have been observed for this gene. |
Source : | E. coli |
Species : | Mouse |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | 14kDa as determined by SDS-PAGE reducing conditions. |
Protein length : | Val21~Thr131 (Accession # P56473) |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | >95% |
Characteristic : | The isoelectric point is 8.6. |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as liquid form in Phosphate buffered saline(PBS), pH7.4. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | Agrp agouti related neuropeptide [ Mus musculus (house mouse) ] |
Official Symbol : | Agrp |
Synonyms : | Art; Agrt; orexigenic neuropeptide; agouti-related protein |
Gene ID : | 11604 |
mRNA Refseq : | NM_001271806.1 |
Protein Refseq : | NP_001258735.1 |
UniProt ID : | P56473 |
Products Types
◆ Recombinant Protein | ||
AGRP-3246H | Recombinant Human AGRP protein(Ser85-Thr132), hFc-tagged | +Inquiry |
AGRP-94H | Recombinant Human AGRP Protein, His-tagged | +Inquiry |
AGRP-814M | Recombinant Mouse AGRP Protein (Ser82-Thr131), HlgG1 Fc-tagged | +Inquiry |
AGRP-311H | Recombinant Human AGRP Protein (21-132 aa), His-SUMO-tagged | +Inquiry |
Agrp-553M | Recombinant Mouse Agrp Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
AGRP-2471HCL | Recombinant Human AGRP cell lysate | +Inquiry |
AGRP-1142MCL | Recombinant Mouse AGRP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAGRP and the melanocortin system are potential targets for developing anti-obesity therapies, and research is ongoing to develop selective agonists or antagonists to modulate AGRP signaling.
AGRP is also implicated in the modulation of autonomic functions, such as blood pressure regulation and cardiovascular control.
AGRP inhibits the signaling of melanocortin receptors, leading to reduced cAMP production and affecting intracellular pathways involved in appetite and energy regulation.
AGRP acts as a key neuropeptide in the hypothalamus, integrating signals from peripheral tissues to regulate energy homeostasis, appetite, and body weight.
AGRP functions as an antagonist to melanocortin receptors, counteracting the effects of α-melanocyte-stimulating hormone (α-MSH), which promotes satiety and energy expenditure.
Yes, AGRP can interact with other neuropeptides, such as neuropeptide Y (NPY), and together they influence the central regulation of appetite and energy balance.
Dysregulation of AGRP expression or activity has been suggested to contribute to the development of certain eating disorders, such as binge eating disorder or hyperphagia.
While AGRP itself is not typically used as a diagnostic marker, studying its expression levels or genetic variations may provide insights into the risk and development of metabolic disorders.
AGRP acts on the melanocortin receptors in the brain, inhibiting their activation and resulting in an increase in appetite and a decrease in energy expenditure.
AGRP levels may have potential as a biomarker for monitoring the response to weight loss interventions, but further research is needed to establish its clinical utility.
Customer Reviews (5)
Write a reviewThis company offers a wide range of recombinant proteins at competitive prices.
The pricing structure for their proteins is transparent and reasonable.
The customer support team was extremely helpful and responsive, providing detailed information about the products.
We are exceedingly satisfied with the quality of this protein.
The exceptional quality of the proteins makes it a great value for the cost.
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