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Recombinant Mouse AKIP1 Protein

Cat.No. : AKIP1-1484M
Product Overview : Recombinant Mouse AKIP1 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Mouse
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Akip1 A kinase (PRKA) interacting protein 1 [ Mus musculus ]
Official Symbol : AKIP1
Gene ID : 57373
mRNA Refseq : NM_020616.1
Protein Refseq : NP_065641.1
MIM :
UniProt ID : Q9JJR5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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Is AKIP1 involved in any signaling pathways? 04/24/2023

AKIP1 has been implicated in several signaling pathways. It has been reported to modulate the activity of the ERK1/2 (extracellular signal-regulated kinase 1/2) pathway, a major signaling cascade involved in cell proliferation and survival. When AKIP1 interacts with the oncogenic protein RAF1, it can enhance ERK1/2 signaling.

Can AKIP1 be used as a biomarker for any diseases? 04/05/2023

AKIP1 has been investigated as a potential biomarker in certain cancers. For example, increased AKIP1 expression has been observed in breast, prostate, and colorectal cancer tissues compared to normal tissues, suggesting its potential as a diagnostic or prognostic biomarker. However, further studies are needed to validate its utility as a biomarker and establish its clinical significance in disease diagnosis and management.

How is AKIP1 involved in transcriptional regulation? 03/11/2023

AKIP1 has been found to modulate transcriptional activity by interacting with transcription factors and co-regulators. It can associate with components of the basal transcriptional machinery and influence gene expression. AKIP1 has been shown to regulate the activity of NF-κB and modulate the transcription of target genes involved in inflammation and cancer.

Can post-translational modifications affect AKIP1 function? 10/26/2022

Yes, post-translational modifications can impact AKIP1 function. Phosphorylation of AKIP1 by protein kinases such as PKA (protein kinase A) and MAPK (mitogen-activated protein kinase) can regulate its interaction with other proteins and affect its subcellular localization. Acetylation of AKIP1 by the acetyltransferase p300/CBP (CREB-binding protein) can enhance its stability and prevent proteasomal degradation.

Does AKIP1 have any role in cell cycle regulation? 07/08/2022

Limited research suggests that AKIP1 may play a role in cell cycle regulation by influencing cyclin D1 expression and cyclin-dependent kinase activity. However, the exact mechanisms by which AKIP1 affects cell cycle progression and checkpoints are not yet well understood and require further investigation.

How is AKIP1 regulated in the cell? 02/27/2022

AKIP1 regulation is not fully understood, but it can be influenced by various factors. It is known that certain cellular signaling pathways, such as the PKA signaling pathway, can modulate AKIP1 expression and activity. Additionally, post-translational modifications, including phosphorylation, can impact AKIP1 function. Further investigation is required to unravel the complete mechanisms of AKIP1 regulation.

Is AKIP1 localized to specific cellular compartments? 09/25/2021

AKIP1 can be present in different cellular compartments depending on its interacting partners and cellular context. It has been found in the nucleus, cytoplasm, and mitochondria. AKIP1 localization is influenced by factors such as phosphorylation and protein-protein interactions.

Can AKIP1 be targeted for drug development or therapeutic purposes? 05/31/2020

Yes, AKIP1 has been explored as a potential therapeutic target in cancer treatment. Inhibiting AKIP1 expression or activity may help to suppress tumor growth, metastasis, and enhance the efficacy of existing anticancer therapies. However, the development of specific AKIP1-targeting drugs is still in the early stages and requires further research and validation.

Does AKIP1 have any role in mitochondrial function? 05/24/2020

Yes, AKIP1 has been found to localize to the mitochondria and play a role in mitochondrial function. It has been implicated in regulating mitochondrial protein import, maintaining mitochondrial membrane potential, and promoting mitochondrial oxidative phosphorylation. AKIP1 has also been associated with mitochondrial dynamics, particularly mitochondrial fission.

Are there any known protein partners or interacting proteins of AKIP1? 12/28/2019

Yes, AKIP1 interacts with several proteins to carry out its functions. Some known protein partners of AKIP1 include the regulatory subunits of PKA, HDAC1 (histone deacetylase 1), p65 subunit of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), and STAT3 (signal transducer and activator of transcription 3), among others.

Is AKIP1 involved in DNA repair processes? 05/09/2019

There is limited evidence suggesting that AKIP1 may have a role in DNA repair processes. It has been reported to interact with the DNA repair protein Ku70, which is involved in non-homologous end joining (NHEJ), a DNA repair pathway. AKIP1 overexpression in breast cancer cells has been shown to enhance the repair of radiation-induced DNA damage, possibly through its interaction with Ku70.

How does AKIP1 interact with PKA? 04/09/2019

AKIP1 binds to the regulatory subunits of PKA and inhibits its activity. This interaction prevents the activation of PKA and influences downstream signaling pathways. AKIP1 may also participate in regulating the localization of PKA within the cell.

Does AKIP1 have any interaction with other proteins? 12/29/2017

Yes, AKIP1 has been found to interact with several proteins. It has been reported to interact with the androgen receptor (AR), a transcription factor involved in male sexual development, and play a role in AR-mediated gene transcription. AKIP1 has also been shown to interact with the DNA repair protein Ku70, as mentioned earlier, and contribute to DNA repair processes. Additionally, AKIP1 has been found to interact with components of the TACC (Transforming Acidic Coiled-Coil) family of proteins, which are involved in spindle assembly and cell division.

How is AKIP1 regulated at the transcriptional level? 11/16/2017

The transcriptional regulation of AKIP1 is not well understood. However, several studies have identified potential transcription factors that can bind to the promoter region of the AKIP1 gene and modulate its expression. For example, the transcription factors Sp1 and Sp3 have been shown to interact with the AKIP1 promoter and activate its transcription. Additionally, the tumor suppressor p53 has been reported to bind to the AKIP1 promoter and negatively regulate its expression.

Is AKIP1 implicated in cancer development or progression? 09/10/2017

AKIP1 has been found to be involved in various aspects of cancer development and progression. Its overexpression has been observed in several types of tumors, and it promotes cell proliferation, migration, invasion, and resistance to cell death. It is considered a potential oncogene and a target for cancer therapy.

Are there any known AKIP1 orthologs in other species? 02/19/2017

Yes, AKIP1 has orthologs in various species. Human AKIP1 shares high sequence similarity with AKIP1 proteins in other mammals, such as mice, rats, and dogs. Additionally, orthologs of AKIP1 have been identified in non-mammalian species, including chicken, zebrafish, and fruit fly. These orthologs likely perform similar functions to human AKIP1, although their exact roles may vary between species.

Are there any known mutations in the AKIP1 gene? 02/14/2017

There have been limited studies investigating mutations in the AKIP1 gene. However, some studies have identified single nucleotide polymorphisms (SNPs) in the AKIP1 gene that may be associated with certain diseases and conditions. For example, a specific SNP in the AKIP1 gene has been found to be associated with an increased risk of developing schizophrenia in some populations. Further research is needed to fully understand the impact of these mutations and their role in disease.

Are there any known diseases or disorders associated with AKIP1? 01/04/2017

While AKIP1 is not directly linked to any specific diseases, altered expression or dysregulation of AKIP1 has been observed in several cancers, including breast, prostate, colorectal, and lung cancer. Its overexpression in cancer cells has been associated with tumor progression, metastasis, and drug resistance. AKIP1 may serve as a potential therapeutic target in cancer treatment.

Are there any known genetic mutations in the AKIP1 gene? 08/05/2016

Mutations in the AKIP1 gene are relatively rare and have not been extensively studied. However, some studies have suggested potential associations between AKIP1 gene mutations and certain diseases, such as prostate cancer. Further research is needed to understand the significance of these mutations.

Can AKIP1 be used as a biomarker in cancer diagnosis or prognosis? 04/15/2016

The utility of AKIP1 as a biomarker in cancer diagnosis or prognosis has not been extensively studied. However, some studies have suggested its potential as a prognostic marker in certain cancers, such as breast and lung cancer. Further research is needed to establish its clinical significance as a biomarker.

Customer Reviews (4)

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Reviews
12/06/2022

    The AKIP1 protein exhibits an exceptional level of quality that perfectly aligns with my experimental requirements.

    09/13/2020

      With the AKIP1 protein's excellent attributes, I am confident that it will not only meet but surpass my experimental needs, ensuring accurate and reliable results.

      07/26/2020

        Its superior purity and consistent performance make it an ideal choice to fulfill my research objectives.

        02/01/2020

          the manufacturer of the AKIP1 protein offers outstanding technical support, which adds to the value of this product.

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