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Recombinant Mouse ANG3 Protein

Cat.No. : ANG3-1628M
Product Overview : Recombinant Mouse ANG3 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Mouse
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Ang3 angiogenin, ribonuclease A family, member 3 [ Mus musculus ]
Official Symbol : ANG3
Gene ID : 11730
mRNA Refseq : NM_001123394.2
Protein Refseq : NP_001116866.2
MIM :
UniProt ID : P97802

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (18)

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Are there any known interactions between Ang3 protein and other molecules or proteins? 12/12/2021

Yes, Ang3 protein can interact with various molecules and proteins. For example, it has been shown to bind to lipoprotein particles and inhibit the activity of lipoprotein lipase (LPL). It can also interact with receptors such as integrins and Tie2 receptor, although the functional significance of these interactions is not fully understood. Research is ongoing to better understand the specific molecular interactions involving Ang3 protein and their implications in physiological processes.

How is Ang3 protein related to cardiovascular disease? 06/11/2021

Dysregulation of Ang3 protein levels can contribute to the development of cardiovascular disease. High levels of Ang3 have been associated with elevated LDL cholesterol and triglyceride levels, which are risk factors for cardiovascular disease. In contrast, loss-of-function mutations in the ANGPTL3 gene, resulting in low Ang3 levels, have been linked to lower plasma lipid levels and reduced risk of cardiovascular disease.

Is Ang3 protein expressed in specific tissues or organs? 04/08/2020

Ang3 protein is widely expressed in various tissues and organs. It is found in adipose tissue, liver, skeletal muscle, heart, and other organs involved in lipid metabolism. The expression level of Ang3 may vary in different tissues and can be influenced by factors such as diet, hormones, and metabolic state.

Are there any known diseases or conditions associated with dysregulation of Ang3 protein? 07/27/2019

While Ang3 protein is primarily associated with lipid metabolism, there are currently no specific diseases or conditions directly linked to dysregulation of Ang3. However, dysregulation of lipid metabolism, which Ang3 can influence, is associated with several metabolic disorders such as hyperlipidemia, obesity, and insulin resistance. Further research is needed to determine the specific role of Ang3 in these conditions.

Does Ang3 protein have any implications in cancer? 07/14/2019

There is some evidence suggesting a potential association between Ang3 protein and cancer. Studies have shown altered expression of Ang3 in different cancer types, including hepatocellular carcinoma, pancreatic cancer, and ovarian cancer. However, the exact role of Ang3 in cancer development and progression is not yet fully understood, and further research is needed to elucidate its potential implications in cancer biology.

How is Ang3 protein detected or measured in research or clinical settings? 04/02/2019

Ang3 protein can be detected and measured using various research and clinical techniques. Enzyme-linked immunosorbent assays (ELISAs) or other immunoassays can be used to quantitatively measure Ang3 protein levels in biological samples such as blood or tissues. Additionally, techniques like immunohistochemistry or immunofluorescence can provide qualitative information about the localization and expression of Ang3 in specific tissues or cells.

Are there any ongoing clinical trials targeting Ang3 protein? 02/16/2019

As of now, there are no known ongoing clinical trials specifically targeting Ang3 protein. However, the potential therapeutic relevance of Ang3 in metabolic disorders has generated interest in developing interventions that modulate its activity. Future clinical trials may explore the efficacy and safety of targeting Ang3 for the management of conditions related to dyslipidemia and metabolic health.

How is Ang3 protein being targeted for therapeutic purposes? 01/20/2019

ANGPTL3-targeted therapies, such as evinacumab, have been developed to inhibit Ang3 protein and lower LDL cholesterol and triglyceride levels. These therapies are being used in the treatment of certain lipid disorders, such as homozygous familial hypercholesterolemia (HoFH), as mentioned earlier. By blocking the function of Ang3 protein, these therapies aim to regulate lipid levels and reduce the risk of cardiovascular disease.

Are there any genetic variations or mutations in the Ang3 gene? 12/08/2018

Genetic variations and mutations in the Ang3 gene have been identified. For example, single nucleotide polymorphisms (SNPs) in the Ang3 gene have been associated with variations in plasma lipid levels, including triglycerides and high-density lipoprotein cholesterol (HDL-C). These genetic variations may contribute to individual differences in lipid metabolism and susceptibility to metabolic disorders.

Are there any animal models or knockout studies exploring the role of Ang3 protein? 11/19/2018

Yes, animal models and knockout studies have been conducted to investigate the role of Ang3 protein. For example, studies using Ang3 knockout mice have demonstrated altered triglyceride metabolism and lipid accumulation in various tissues. These models provide valuable insights into the function and regulation of Ang3 and help examine its potential as a therapeutic target.

Are there any known interactions between Ang3 and other proteins or molecules? 07/27/2018

The interactions between Ang3 protein and other molecules or proteins are still being investigated. Ang3 has been shown to interact with lipoprotein lipase (LPL), serving as an inhibitor of its activity. Additionally, some studies suggest that Ang3 may interact with receptors or other signaling molecules involved in lipid metabolism. Further research is needed to fully elucidate the molecular interactions of Ang3.

Is Ang3 protein involved in cardiovascular health? 07/23/2018

Yes, Ang3 protein is implicated in cardiovascular health. Dysregulation of lipid metabolism, including elevated levels of triglyceride-rich lipoproteins, is a risk factor for cardiovascular diseases such as atherosclerosis and coronary artery disease. Ang3, by inhibiting LPL activity, can contribute to the accumulation of triglyceride-rich lipoproteins and potentially increase the risk of cardiovascular complications.

Is there any therapeutic potential for targeting Ang3 protein? 09/23/2016

There is ongoing research into the therapeutic potential of targeting Ang3 protein. Inhibiting Ang3 activity could potentially enhance the clearance of triglyceride-rich lipoproteins and improve lipid metabolism, offering a therapeutic approach for managing metabolic disorders such as hyperlipidemia and obesity-related complications. However, further studies are needed to fully understand the role of Ang3 and validate its potential as a therapeutic target.

Are there any associations between Ang3 protein and obesity? 07/20/2016

Yes, there is evidence that Ang3 protein may be involved in the development of obesity. Studies have shown that Ang3 levels are elevated in obese individuals, particularly in those with metabolic disorders such as insulin resistance and type 2 diabetes. Ang3 has been suggested as a potential biomarker for obesity-related metabolic complications.

What are the known functions of Ang3 protein in the body? 04/22/2016

Ang3 protein has multiple functions in the body. It is primarily involved in lipid metabolism, particularly the regulation of triglyceride-rich lipoproteins. Ang3 acts as an inhibitor of lipoprotein lipase (LPL), an enzyme responsible for breaking down triglycerides in the bloodstream. By inhibiting LPL activity, Ang3 prolongs the circulation time of triglyceride-rich lipoproteins and promotes their uptake by tissues such as adipose tissue and skeletal muscle.

Are there any genetic disorders associated with mutations in the ANGPTL3 gene? 04/02/2016

Yes, mutations in the ANGPTL3 gene can give rise to genetic disorders that affect lipid metabolism. One example is familial combined hypolipidemia, characterized by low levels of LDL cholesterol and triglycerides. On the other hand, loss-of-function mutations in the ANGPTL3 gene can lead to familial combined hyperlipidemia, characterized by high LDL cholesterol and triglyceride levels.

Can Ang3 protein influence other metabolic processes apart from lipid metabolism? 03/23/2016

Yes, Ang3 protein has been shown to have roles in other metabolic processes beyond lipid metabolism. It has been implicated in glucose homeostasis and insulin sensitivity. Studies have suggested that Ang3 may play a role in regulating glucose uptake and utilization in various tissues, including skeletal muscle and adipose tissue.

How is Ang3 protein regulated in the body? 03/13/2016

The expression and activity of Ang3 protein can be regulated by various factors. Insulin, for example, has been shown to upregulate Ang3 expression in adipose tissue. Additionally, dietary factors such as fasting and high-fat diets can influence Ang3 levels. Various transcription factors and signaling pathways are involved in the regulation of Ang3 gene expression, but the exact mechanisms are still being studied.

Customer Reviews (4)

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Reviews
05/04/2020

    they can provide fast and efficient delivery services, minimizing any potential delays and allowing researchers to proceed with their studies in a timely manner.

    06/10/2019

      a manufacturer with a responsive and dedicated customer support team can address any concerns or queries that researchers may have.

      10/15/2018

        This includes rigorous quality control measures to ensure the consistency and purity of the protein, thereby reducing variability in the experimental outcomes.

        09/08/2017

          With expert assistance and reliable product quality, researchers can conduct their experiments with confidence, enabling them to contribute to advancements in the field and potentially improve future therapeutic interventions.

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