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Recombinant Mouse Apom Protein, His-tagged

Cat.No. : Apom-519M
Product Overview : Recombinant Mouse Apom(Met20~Lys190) fused with His tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Source : E. coli
Species : Mouse
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 24.5kDa
Protein length : Met20~Lys190
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : > 97%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : Apom apolipoprotein M [ Mus musculus ]
Official Symbol : Apom
Synonyms : APOM; apolipoprotein M; apo-M; G3a; NG20; 1190010O19Rik;
Gene ID : 55938
mRNA Refseq : NM_018816
Protein Refseq : NP_061286
UniProt ID : Q9Z1R3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (12)

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Can genetic variations in the APOM gene influence APOM protein levels? 02/24/2023

Yes, genetic variations in the APOM gene can impact APOM protein levels. Certain single nucleotide polymorphisms (SNPs) or mutations within the APOM gene have been associated with altered APOM expression levels. For example, specific APOM gene variants have been linked to lower APOM protein levels in plasma and changes in HDL cholesterol levels, which may contribute to cardiovascular disease risk.

Where is APOM protein primarily expressed? 11/11/2022

APOM protein is mainly expressed in the liver and kidneys. It is also present in other tissues, such as the intestines, adrenal glands, and spleen, but at lower levels.

Are there any known regulators of APOM protein expression? 08/27/2021

Yes, there are several known regulators of APOM protein expression. Transcription factors, such as hepatocyte nuclear factor 1 (HNF-1), liver X receptors (LXRs), and peroxisome proliferator-activated receptor gamma (PPARγ), have been identified as regulators of APOM gene expression. Additionally, factors like insulin, statins, and sex hormones (such as estrogen) can also influence APOM protein levels.

Are there any interactions between APOM protein and other proteins or molecules? 06/02/2021

Yes, APOM protein can interact with other proteins and molecules. In addition to binding to S1P, APOM has been shown to interact with components of the HDL particle, such as apolipoprotein A-I (apoA-I). It can also interact with enzymes involved in the metabolism of lipids, such as sphingosine kinase 1 (SphK1) and sphingosine-1-phosphate lyase (S1PL), which regulate S1P levels.

Can APOM protein be used as a biomarker for any diseases? 07/21/2020

APOM protein has been investigated as a potential biomarker for certain diseases. Research suggests that APOM levels in plasma or HDL particles could be used as a biomarker for evaluating cardiovascular risk and predicting the progression of metabolic disorders. However, further studies are needed to establish its utility as a clinical biomarker.

Does APOM protein have any known genetic variants or mutations? 05/26/2020

Yes, there are several known genetic variants and mutations in the APOM gene. Some studies have linked certain APOM gene variants to altered levels of APOM protein, which can impact lipid metabolism and the risk of developing cardiovascular diseases.

Are there any drug targets related to APOM protein? 10/12/2019

Given the role of APOM protein in lipid metabolism and its association with cardiovascular diseases, it has been considered as a potential drug target. However, no specific drugs targeting APOM are currently available. Further research is needed to explore potential therapeutic strategies aimed at modulating APOM levels or function for clinical applications.

Are there any known therapeutic strategies targeting APOM protein? 08/16/2019

Currently, there are no approved therapeutic strategies specifically targeting APOM protein. However, given its involvement in lipid metabolism and cardiovascular health, manipulating APOM levels or function could hold therapeutic potential. Future research may explore approaches such as gene therapy, potential drug candidates, or interventions aimed at modulating APOM expression or its interaction with S1P to potentially impact lipid disorders and cardiovascular diseases.

Is APOM protein associated with any diseases? 05/15/2018

APOM protein has been implicated in various diseases, particularly those related to lipid metabolism and cardiovascular health. For example, low levels of APOM in HDL particles have been associated with increased risk of atherosclerosis, coronary artery disease, and impaired glucose metabolism.

Can APOM protein affect the composition of HDL particles? 08/01/2017

Yes, APOM protein can influence the composition of HDL particles. Its binding to S1P within HDL can modify the lipid content and structure of these particles. This, in turn, can impact the functionality and biological properties of HDL, such as its ability to promote reverse cholesterol transport and exert anti-inflammatory effects.

How is APOM protein involved in the metabolism of sphingosine-1-phosphate? 07/30/2017

APOM protein binds to sphingosine-1-phosphate (S1P) and helps transport it within high-density lipoprotein (HDL) particles. This interaction with APOM stabilizes S1P and allows it to circulate in the bloodstream, playing a role in various biological processes, including immune cell trafficking, angiogenesis, and vascular biology.

What cellular processes are influenced by APOM protein? 07/11/2016

APOM protein is involved in several cellular processes, including lipid metabolism, lipoprotein biogenesis and remodeling, immune cell activation and migration, endothelial cell integrity, and vascular homeostasis. Its interaction with S1P and its role in HDL metabolism have implications for various physiological and pathological processes, such as atherosclerosis, inflammation, and cardiovascular health.

Customer Reviews (4)

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Reviews
04/08/2021

    Securing a protein of exceptional quality is crucial to meet the demands of my experiments, and I am confident that the APOM protein offered by the manufacturer will fulfill my requirements.

    09/18/2018

      This reliable and punctual supply enables me to proceed with my experiments without unnecessary delays, ensuring an efficient research process.

      05/18/2018

        the APOM protein, combined with the manufacturer's outstanding technical support and commitment to delivering high-quality products, presents an excellent opportunity for my research.

        07/11/2016

          Whether it's troubleshooting guidance, experimental design suggestions, or elucidating optimal storage conditions, their expertise can significantly accelerate the progress of my trials.

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