Recombinant Mouse ARF3 Protein
Cat.No. : | ARF3-1839M |
Product Overview : | Recombinant Mouse ARF3 full length or partial length protein was expressed. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian Cells |
Species : | Mouse |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC. |
Storage Buffer : | PBS buffer |
Gene Name : | Arf3 ADP-ribosylation factor 3 [ Mus musculus ] |
Official Symbol : | ARF3 |
Gene ID : | 11842 |
mRNA Refseq : | NM_007478.3 |
Protein Refseq : | NP_031504.1 |
MIM : | |
UniProt ID : | P61205 |
Products Types
◆ Recombinant Protein | ||
ARF3-659M | Recombinant Mouse ARF3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Arf3-635M | Recombinant Mouse Arf3 Protein, MYC/DDK-tagged | +Inquiry |
ARF3-405R | Recombinant Rat ARF3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARF3-237H | Recombinant Human ARF3, His tagged | +Inquiry |
Arf3-3207R | Recombinant Rat Arf3, His-tagged | +Inquiry |
◆ Lysates | ||
ARF3-8759HCL | Recombinant Human ARF3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionTargeting ARF3 protein or its associated pathways may have potential therapeutic implications, particularly in diseases characterized by abnormal vesicular trafficking, such as certain types of cancer, neurodegenerative disorders, and viral infections. However, further research is needed to fully explore these therapeutic possibilities.
ARF3 protein contributes to cellular homeostasis by regulating intracellular trafficking and maintaining the proper distribution of proteins and lipids within cells. By ensuring the correct delivery of molecules to their target compartments, ARF3 helps in maintaining cellular integrity and the functioning of organelles.
ARF3 protein can interact with various proteins to carry out its functions. Some known protein-protein interactions include interactions with coat proteins (such as COPI and clathrin), cargo adaptors/receptors (such as AP-1, GGAs, and SNXs), SNARE proteins, and regulators of membrane fusion (such as rab effectors and tethering factors).
While rare, some genetic mutations in the ARF3 gene have been identified in individuals with developmental disorders or neurological conditions, emphasizing the importance of ARF3 protein in proper cellular functioning.
ARF3 protein interacts with cargo receptors or adaptors within the Golgi apparatus or endosomes, mediating the sorting and packaging of specific cargoes into vesicles destined for their respective target compartments.
While there are currently no specific inhibitors or activators for ARF3 protein available for clinical use, several compounds and small molecules have been developed for research purposes that can modulate ARF3 activity or its associated pathways. These molecules can be utilized as tools to investigate the cellular functions of ARF3 and may have future therapeutic applications.
Yes, small molecule inhibitors and activators targeting ARF3 protein or its associated pathways have been developed for research purposes, potentially aiding in drug discovery efforts targeted towards vesicular trafficking-related diseases.
While rare, dysfunction in ARF3 protein has been implicated in certain genetic and neurodegenerative disorders, highlighting its importance in maintaining proper cellular trafficking pathways.
The activation of ARF3 protein can be regulated by various upstream regulators. Small GTPases from the ARF family, such as ARF guanine nucleotide exchange factors (ARFGEFs), facilitate the exchange of GDP for GTP on ARF3, leading to its activation. Additionally, other signaling pathways, such as the phosphoinositide 3-kinase (PI3K) pathway, can also regulate ARF3 activity.
While targeting ARF3 directly may be challenging, modulating its activity or associated pathways could have therapeutic implications. For example, targeting ARFGEFs or ARF3 downstream effectors could potentially alter ARF3-mediated vesicular trafficking and be utilized in the treatment of diseases where this process is dysregulated.
Yes, ARF3 protein can regulate membrane fusion events by interacting with SNARE proteins and other regulators involved in vesicle tethering and fusion processes.
Yes, ARF3 protein can interact with various signaling pathways, including the PI3K-Akt pathway and the Rho GTPase signaling network, to coordinate cellular processes like cell proliferation, survival, and cytoskeletal rearrangements.
Although not extensively studied, dysregulation of ARF3 protein has been implicated in certain diseases. For example, altered ARF3 expression and activity have been observed in neurodegenerative diseases like Alzheimer's and Parkinson's, suggesting a potential role in their pathogenesis.
ARF3 protein is involved in the formation and maintenance of various organelles. By regulating membrane trafficking and vesicle budding, ARF3 helps in the biogenesis of organelles such as the Golgi apparatus, endosomes, and secretory vesicles.
Yes, ARF3 protein has been implicated in synaptic vesicle recycling, axonal transport, and dendritic spine morphogenesis, suggesting its involvement in regulating neuronal function and synaptic plasticity.
Yes, ARF3 protein can be inactivated by GTPase-activating proteins (GAPs), which stimulate the hydrolysis of GTP to GDP, returning ARF3 to its inactive state.
Some effectors of ARF3 protein include COPI and clathrin adaptor proteins, which assist in coat assembly during vesicle formation, as well as phospholipase D, which participates in membrane remodeling events.
Cellular stress conditions, such as oxidative stress or nutrient deprivation, can modulate ARF3 protein activity. Various stress-responsive signaling pathways, including the MAPK pathway, can regulate ARF3 activation or inhibit its function to adapt cellular responses and maintain cell viability under stress.
ARF3 protein functions as a molecular switch by cycling between an active GTP-bound form and an inactive GDP-bound form. In its active state, ARF3 recruits various effectors and regulators to modulate vesicle trafficking processes.
Yes, ARF3 protein has been implicated in cytokinesis, the process of cell division. It is involved in the regulation of membrane trafficking events required for the constriction of the contractile ring and the formation of the cleavage furrow during cytokinesis.
Customer Reviews (8)
Write a reviewWhether I need expertise in experimental optimization or troubleshooting, I can rely on the manufacturer's support to promptly address any concerns or queries.
Its purity and reliability ensure reliable and reproducible results in a variety of research applications.
the manufacturer's support team provides extensive technical assistance, helping researchers navigate any challenges they may face throughout their experiments.
ARF3 protein is known for its versatility and functionality, enabling researchers to explore various biological processes and molecular interactions.
Its versatility and reliability make it a great choice for researchers exploring protein dynamics, function, and interactions.
Its use in EM studies allows researchers to gain insights into the structural details of proteins and their complexes at high resolution.
the ARF3 protein is highly regarded for its excellent performance in WB assays and its significant contribution to protein EM structure analysis.
The ARF3 protein exhibits outstanding performance in enzyme-linked immunosorbent assays (ELISA).
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