Recombinant Mouse Arl14 Protein, Myc/DDK-tagged
Cat.No. : | Arl14-1704M |
Product Overview : | Purified recombinant protein of mouse full-length ADP-ribosylation factor-like 14 (Arl14), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 21.8 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Arl14 ADP-ribosylation factor-like 14 [ Mus musculus (house mouse) ] |
Official Symbol : | Arl14 |
Synonyms : | ARL14; ADP-ribosylation factor-like 14; ADP-ribosylation factor-like protein 14; ADP-ribosylation factor 7; Arf7; 9130014L17Rik; MGC129454; MGC129455 |
Gene ID : | 71619 |
mRNA Refseq : | NM_027843 |
Protein Refseq : | NP_082119 |
UniProt ID : | S4R1T9 |
Products Types
◆ Recombinant Protein | ||
ARL14-4276H | Recombinant Human ARL14 Protein, GST-tagged | +Inquiry |
ARL14-9852H | Recombinant Human ARL14, GST-tagged | +Inquiry |
ARL14-5795Z | Recombinant Zebrafish ARL14 | +Inquiry |
ARL14-27187TH | Recombinant Human ARL14, His-tagged | +Inquiry |
ARL14-2489H | Recombinant Human ADP-Ribosylation Factor-Like 14, His-tagged | +Inquiry |
◆ Lysates | ||
ARL14-8719HCL | Recombinant Human ARL14 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (14)
Ask a questionResearch is ongoing to uncover the precise cellular roles and mechanisms of ARL14. These studies aim to provide further insights into its functions, interactions, and potential implications in cellular processes and diseases.
There is limited information on the potential involvement of ARL14 in cancer. However, some studies have suggested that alterations in ARL14 expression or activity may contribute to tumorigenesis by influencing cellular processes like vesicle trafficking and cell signaling. Further research is needed to fully understand the implications of ARL14 in cancer.
Currently, ARL14 is not widely recognized as a specific biomarker for any diseases. However, ongoing research might uncover potential associations between altered ARL14 levels and specific diseases or conditions.
Several proteins have been identified as potential interacting partners of ARL14, including components of the COPI vesicle coat complex and proteins involved in intracellular vesicle trafficking and membrane remodeling. However, further studies are needed to elucidate the specific protein-protein interactions associated with ARL14.
Post-translational modifications, such as phosphorylation, acetylation, and ubiquitination, have been reported for ARL14. These modifications can regulate its activity, subcellular localization, and interaction with other proteins.
To date, there are no known reports of knockout or transgenic animal models specifically targeting ARL14. Generating such models could provide valuable insights into the physiological roles of ARL14 and its implications in disease.
While the exact cellular pathways involving ARL14 are still being investigated, studies have suggested its potential involvement in the regulation of intracellular vesicle trafficking, protein secretion, and membrane dynamics. These findings contribute to our understanding of its possible cellular functions.
While the precise role of ARL14 in endocytosis and exocytosis is not fully understood, studies suggest that it may participate in regulating vesicle trafficking, which is essential for these cellular processes. Further investigations are needed to decipher the specific mechanisms involving ARL14 in these pathways.
Although the exact involvement of ARL14 in neurological disorders is still unclear, some studies suggest its potential association with neurodegenerative diseases. Therefore, further exploration of ARL14's role in the nervous system may identify potential therapeutic avenues for neurological disorders.
Yes, ARL14 is evolutionarily conserved across various species. It has been identified in both invertebrates and vertebrates, indicating its conserved biological importance throughout evolution.
Currently, there are no known direct associations between ARL14 mutations and specific diseases or disorders. However, alterations in ARL14 levels or activity may potentially impact cellular processes related to vesicle trafficking and protein secretion, which could contribute to certain pathological conditions.
ARL14 shares similarities with other ARL proteins in terms of structure and function. However, it also exhibits distinct features that set it apart from other family members. Comparative studies can help uncover unique aspects of ARL14 and its functional relevance.
Genetic variations, such as single nucleotide polymorphisms (SNPs), have been identified in the ARL14 gene. These variations may impact ARL14 expression or function, potentially influencing cellular processes. The significance and functional consequences of these variations require further investigation.
Since the function of ARL14 is not yet fully understood, it is challenging to target it directly for therapeutic interventions. However, by further elucidating its role in cellular processes, it may be possible to develop strategies to modulate its activity indirectly.
Customer Reviews (10)
Write a reviewARL14 protein has been extensively studied and characterized, allowing researchers to confidently integrate it into their experimental workflows.
Manufacturers can provide researchers with purified and validated ARL5B protein, ensuring its quality and reliability for use in experiments and trials.
The ARL14 protein offered by the manufacturer is of exceptional quality and is expected to perfectly meet my experimental needs.
Its purity and integrity are of the highest standard, ensuring reliable and reproducible results in my research.
Manufacturers may provide documentation of the protein's validation, which includes information about its purity, concentration, stability, and potential contaminants.
The manufacturer's commitment to providing excellent technical support is commendable, as their dedicated team possesses the expertise to solve any issue or query that may arise during my experiments.
They can assist in identifying the most suitable experimental protocols or provide recommendations for optimal usage.
This can be particularly important in clinical trials to ensure accurate and reliable results.
Their prompt assistance and guidance contribute to enhancing the success and efficiency of my work with the ARL14 protein.
If the need arises for larger quantities of ARL14 protein during the later stages of clinical trials, the manufacturer can facilitate scale-up production processes to meet those requirements.
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