Recombinant Mouse Arrdc1 Protein, Myc/DDK-tagged

• Cat.No.: Arrdc1-1729M
• Product Overview: Purified recombinant protein of mouse full-length arrestin domain containing 1 (Arrdc1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles. More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles. By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway.
• Molecular Mass: 46.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Arrdc1 arrestin domain containing 1 [ Mus musculus (house mouse) ]
• Official Symbol: Arrdc1
• Synonyms: Arrdc1; arrestin domain containing 1; AI957342; BC004091; arrestin domain-containing protein 1; alpha-arrestin 1
• Gene ID: 215705
• mRNA Refseq: NM_001162485
• Protein Refseq: NP_001155957
• UniProt ID: Q99KN1