Recombinant Mouse Atrn Protein, MYC/DDK-tagged

• Cat.No.: Atrn-825M
• Product Overview: Purified recombinant protein of full-length mouse attractin (Atrn), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.

Specification

• Description: This gene encodes a widely expressed transmembrane glycoprotein that plays important roles in diverse physiological processes such as regulation of hair pigmentation, monocyte-T cell interaction and control of energy homeostasis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Certain mutations in this gene are responsible for the mahogany mouse phenotype of dark brown or black coat on a normally agouti background. Mice with loss-of-function mutations in this gene exhibit black coat color, tremor, adiposity, higher basal metabolic rate, juvenile-onset hypomyelination and age-dependent spongiform neurodegeneration of the central nervous system.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 158.5 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Atrn attractin [ Mus musculus (house mouse) ]
• Official Symbol: Atrn
• Synonyms: Atrn; attractin; mg; Mgca; AW558010; attractin; protein mahogany
• Gene ID: 11990
• mRNA Refseq: NM_009730
• Protein Refseq: NP_033860
• UniProt ID: Q9WU60

Reviews

11/13/2022

ATRN's exceptional purity ensures accurate and reproducible experimental results.

07/07/2022

The protein manufacturer's products are backed by strong scientific research and development to provide customers with cutting-edge solutions.

03/04/2022

Because ATRN is resistant to degradation and its stability under various experimental conditions makes it the best choice for Western blot analysis.

Q&As

What diseases or symptoms can be caused by ATRN mutations?

ATRN gene mutations may lead to hereditary hemorrhagic telangiectasia and other diseases. The main features of the disease include telangiectasia on the skin and mucosa, epistaxis, and bleeding in internal organs.

Are there other genes that interact with the ATRN gene?

Yes, the ATRN gene may interact with other genes involved in the regulation of cell development and function, such as the Netrin-1 gene in nervous system development. These interactions may affect the function and regulatory network of ATRN genes.

Is the ATRN gene regulated?

Yes, ATRN gene expression is affected by a variety of regulatory factors, including binding of transcription factors, activation of signaling pathways, etc. These regulatory mechanisms ensure the adaptability and stability of the ATRN gene.

Is ATRN gene associated with cancer?

At present, no direct association between ATRN gene and cancer has been found. However, the regulatory role of ATRN genes in cell proliferation and differentiation may be indirectly related to tumorigenesis and progression.

What is the expression pattern of ATRN gene?

The ATRN gene is widely expressed in the human body, but its expression level may vary in different tissues and organs. Its expression is higher in brain, retina, kidney and other tissues.

What progress has been made in the research of ATRN gene?

The research on ATRN gene mainly focuses on the analysis of its structure and function, the exploration of its regulatory mechanism, and the relationship with genetic diseases. So far, several important findings have been made regarding the function and regulation of ATRN genes.