Recombinant Mouse Aunip Protein, Myc/DDK-tagged

• Cat.No.: Aunip-1787M
• Product Overview: Purified recombinant protein of mouse full-length aurora kinase A and ninein interacting protein (Aunip), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 37.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Aunip aurora kinase A and ninein interacting protein [ Mus musculus (house mouse) ]
• Official Symbol: Aunip
• Synonyms: Aunip; aurora kinase A and ninein interacting protein; Aunip; Clhc1; 2610002D18Rik; aurora kinase A and ninein-interacting protein; aurora A-binding; clathrin heavy chain linker domain containing 1
• Gene ID: 69885
• mRNA Refseq: NM_001081099
• Protein Refseq: NP_001074568
• UniProt ID: E9Q6Z5