Recombinant Mouse B4galt1 Protein, Myc/DDK-tagged

• Cat.No.: B4galt1-1806M
• Product Overview: Purified recombinant protein of Mouse UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4galt1), full length, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene encodes two distinct enzyme isoforms, a long membrane-bound form and a short soluble form. These alternate isoforms are thought to be produced through alternative nested transcription initiation and different in-frame start codon usage. These enzymes catalyze the transfer of galactose to acceptor sugars, such as N-acetylglucosamine and glucose. The long form of this enzyme is localized to the trans-Golgi membrane and is involved in glycoconjugate biosynthesis. The short form functions in lactose biosynthesis though formation of a heterodimer with alpha-lactalbumin.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 44.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris-HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 [ Mus musculus (house mouse) ]
• Official Symbol: B4galt1
• Synonyms: B4GALT1; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1; beta-1,4-galactosyltransferase 1; b4Gal-T1; B-1,4-GalT1; beta4Gal-T1; beta-1,4-GalT; beta-1,4-GalT1; beta-1,4-GalTase 1; b1,4-Galactosyltransferase I; beta 1,4-Galactosyltransferase I; galactosyltransferase 2 beta 1, 4; beta-1,4-galactosyltransferase (short form); glycoprotein galactosyltransferase beta 1, 4; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 1; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1; GalT; Ggtb; Ggtb2; AA407245; B-1,4-GalT
• Gene ID: 14595
• mRNA Refseq: NM_022305
• Protein Refseq: NP_071641
• UniProt ID: P15535

Reviews

10/14/2021

Quick shipping, excellent quality.

10/03/2021

High quality, excellent performance.

05/16/2021

Reliable, good for research.

Q&As

How does B4GALT1 contribute to the synthesis of glycoproteins and glycolipids?

It synthesizes lactosylceramide, a building block for complex glycosphingolipids in glycoprotein and glycolipid synthesis.

What is the primary function of B4GALT1 in cellular processes?

B4GALT1 is crucial for glycosylation, attaching galactose to proteins and lipids.

In which cells or tissues is B4GALT1 predominantly expressed?

B4GALT1 is widely expressed but has higher activity in the liver, kidney, and intestine.

What therapeutic strategies are being explored targeting B4GALT1 for disease treatment?

Therapeutic strategies include targeting B4GALT1 to modulate its activity in cancer and other diseases.

How is B4GALT1 implicated in cancer progression and metastasis?

Altered B4GALT1 expression is linked to cancer, influencing tumor growth and metastasis.

Are there known genetic mutations in B4GALT1 associated with specific diseases or conditions?

Genetic mutations in B4GALT1 are associated with some rare metabolic disorders.

What role does B4GALT1 play in immune system function?

It modulates immune responses by altering glycosylation patterns on immune cells.