Recombinant Mouse Bloc1s2 Protein, Myc/DDK-tagged

• Cat.No.: Bloc1s2-1873M
• Product Overview: Purified recombinant protein of mouse full-length biogenesis of lysosomal organelles complex-1, subunit 2 (Bloc1s2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.
• Molecular Mass: 11.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 [ Mus musculus (house mouse) ]
• Official Symbol: Bloc1s2
• Synonyms: BLOC1S2; biogenesis of lysosome-related organelles complex-1, subunit 2; biogenesis of lysosome-related organelles complex 1 subunit 2; BLOC-1 subunit 2; BLOS2; 2410089B13Rik
• Gene ID: 73689
• mRNA Refseq: NM_028607
• Protein Refseq: NP_082883
• UniProt ID: Q9CWG9