Recombinant Mouse Bmt2 Protein, MYC/DDK-tagged
Cat.No. : | Bmt2-173M |
Product Overview : | Purified recombinant protein of full-length mouse base methyltransferase of 25S rRNA 2 (Bmt2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. |
Source : | HEK293T |
Species : | Mouse |
Tag : | MYC/DDK |
Molecular Mass : | 46 kDa |
Purity : | >80%, as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Bmt2 base methyltransferase of 25S rRNA 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Bmt2 |
Synonyms : | Bmt2; base methyltransferase of 25S rRNA 2; AI666701; B630005N14Rik; S-adenosylmethionine sensor upstream of mTORC1; UPF0532 protein C7orf60 homolog; probable methyltransferase BMT2 homolog; probable methyltransferase BTM2 homolog; EC 2.1.1.- |
Gene ID : | 101148 |
mRNA Refseq : | NM_175312 |
Protein Refseq : | NP_780521 |
UniProt ID : | Q8BXK4 |
Products Types
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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