Recombinant Mouse Bmt2 Protein, MYC/DDK-tagged


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Recombinant Mouse Bmt2 Protein, MYC/DDK-tagged

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Cat.No. : Bmt2-173M
Product Overview : Purified recombinant protein of full-length mouse base methyltransferase of 25S rRNA 2 (Bmt2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.
Source : HEK293T
Species : Mouse
Molecular Mass : 46 kDa
Purity : >80%, as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Bmt2 base methyltransferase of 25S rRNA 2 [ Mus musculus (house mouse) ]
Official Symbol : Bmt2
Synonyms : Bmt2; base methyltransferase of 25S rRNA 2; AI666701; B630005N14Rik; S-adenosylmethionine sensor upstream of mTORC1; UPF0532 protein C7orf60 homolog; probable methyltransferase BMT2 homolog; probable methyltransferase BTM2 homolog; EC 2.1.1.-
Gene ID : 101148
mRNA Refseq : NM_175312
Protein Refseq : NP_780521
UniProt ID : Q8BXK4

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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