Recombinant Mouse Brme1 Protein, Myc/DDK-tagged

• Cat.No.: Brme1-1422M
• Product Overview: Purified recombinant protein of mouse full-length RIKEN cDNA 4930432K21 gene (4930432K21Rik), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand berak (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 64.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Brme1 break repair meiotic recombinase recruitment factor 1 [ Mus musculus (house mouse) ]
• Official Symbol: Brme1
• Synonyms: Brme1; break repair meiotic recombinase recruitment factor 1; MRM; Meiok21; 4930432K21Rik; break repair meiotic recombinase recruitment factor 1; uncharacterized protein C19orf57 homolog; BRCA2 and MEILB2-associating protein 1; meiotic recombination modulator
• Gene ID: 74666
• mRNA Refseq: NM_029045
• Protein Refseq: NP_083321
• UniProt ID: Q6DIA7