Recombinant Mouse Brms1 Protein, MYC/DDK-tagged

• Cat.No.: Brms1-328M
• Product Overview: Purified recombinant protein of full-length mouse breast cancer metastasis-suppressor 1 (cDNA clone MGC:6927 IMAGE:2811430), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 16.1 kDa
• Purity: >80%, as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Brms1 breast cancer metastasis-suppressor 1 [ Mus musculus (house mouse) ]
• Official Symbol: Brms1
• Synonyms: Brms1; breast cancer metastasis-suppressor 1; AV003220; AW554636; breast cancer metastasis-suppressor 1 homolog
• Gene ID: 107392
• mRNA Refseq: NM_134155
• Protein Refseq: NP_598916
• UniProt ID: Q99N20