Recombinant Mouse Brsk2 Protein, Myc/DDK-tagged
Cat.No. : | Brsk2-1895M |
Product Overview : | Purified recombinant protein of mouse full-length BR serine/threonine kinase 2 (Brsk2), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-175 can inhibit insulin secretion, BRSK2 phosphorylated at Thr-261 can promote insulin secretion. Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 80.4 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Brsk2 BR serine/threonine kinase 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Brsk2 |
Synonyms : | BRSK2; BR serine/threonine kinase 2; serine/threonine-protein kinase BRSK2; BR serine/threonine-protein kinase 2; serine/threonine-protein kinase SAD-A; brain-specific serine/threonine-protein kinase 2; SADA; SAD-A; 4833424K13Rik |
Gene ID : | 75770 |
mRNA Refseq : | NM_001009930 |
Protein Refseq : | NP_001009930 |
UniProt ID : | Q69Z98 |
Products Types
◆ Recombinant Protein | ||
BRSK2-1172H | Recombinant Human BRSK2 Protein (T2-P736), Tag Free | +Inquiry |
BRSK2-1173H | Recombinant Human BRSK2 Protein (T2-P736), GST tagged | +Inquiry |
BRSK2-1094M | Recombinant Mouse BRSK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
BRSK2-351H | Recombinant Human BRSK2 Protein, GST-tagged | +Inquiry |
BRSK2-301152H | Recombinant Human BRSK2 protein, GST-tagged | +Inquiry |
◆ Lysates | ||
BRSK2-8403HCL | Recombinant Human BRSK2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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