Recombinant Mouse C-type Lectin Domain Family 4, Member N, Fc Chimera

• Cat.No.: Clec4n-2122M
• Product Overview: Recombinant Mouse Clec4n was produced inHEK 293 cells.The extracellular domain of dectin-2 (aa 44-209) is fused at the N-terminus to the Fc portion of human IgG1. MW = ~55kDa (SDS-PAGE).

Specification

• Species: Mouse
• Source: HEK293
• Tag: Fc
• Protein Length: 44-209 a.a.
• Description: Dectin-2 (dendritic cell-associated C-type lectin-2) is a lectin that has been reported to bind to zymosan as well as to hyphae of organisms such asCandida albicans. Dectin-2 exhibits specific recognition of high-mannose structures. Activation of Dectin-2 leads to phosphorylation of FcRg and up-regulated secretion of TNFα and IL-1ra. Dectin-2 might act on inflammatory macrophages and DC to detect pathogenic organisms and possibly endogenous glycoproteins.
• Purity: ≥95% (SDS-PAGE).
• Concentration: 1mg/ml after reconstitution.
• Formulation: Lyophilized. Contains PBS.
• Reconstitution: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
• Endotoxin Content: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
• Stability: Stable for at least 6 months after receipt when stored at -20°C.

Gene Information

• Gene Name: Clec4n C-type lectin domain family 4, member n [ Mus musculus ]
• Synonyms: Clec4n; C-type lectin domain family 4, member n; Nkcl; Clec6a; Clecsf10; C-type lectin domain family 6 member A; dectin-2; DC-associated C-type lectin 2; natural killer complex lectin; C-type lectin superfamily member 10; dendritic cell-associated C-type lectin 2; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10
• Gene ID: 56620
• mRNA Refseq: NM_020001
• Protein Refseq: NP_064385
• UniProt ID: Q9JKF4
• Chromosome Location: 6 F3; 6 55.0 cM
• Function: Binding; sugar binding