Recombinant Mouse C2cd2l Protein, Myc/DDK-tagged

• Cat.No.: C2cd2l-1916M
• Product Overview: Purified recombinant protein of mouse full-length C2 calcium-dependent domain containing 2-like (C2cd2l), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane. It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling. Plays a key role in the coordination of Ca2+ and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers. In response to elevation of cytosolic Ca2+, it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane. Positively regulates insulin secretion in response to glucose. Phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 76.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: C2cd2l C2 calcium-dependent domain containing 2-like [ Mus musculus (house mouse) ]
• Official Symbol: C2cd2l
• Synonyms: C2CD2L; C2 calcium-dependent domain containing 2-like; C2 domain-containing protein 2-like; transmembrane protein 24; Tmem24; 1300006O23Rik
• Gene ID: 71764
• mRNA Refseq: NM_027909
• Protein Refseq: NP_082185
• UniProt ID: Q80X80