Recombinant Mouse Car9 protein, His-tagged

Cat.No. : Car9-7845M
Product Overview : Recombinant Mouse Car9 aa. (Glu88~Glu280 (Accession # Q8VHB5)) fused with N-terminal His tag was produced in E. coli cells.
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Source : E. coli
Species : Mouse
Tag : His
Form : Freeze-dried powder
Molecular Mass : 23 kDa as determined by SDS-PAGE reducing conditions.
Protein length : Glu88~Glu280 (Accession # Q8VHB5)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 5.4.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage Buffer : Supplied as liquid form in Phosphate buffered saline(PBS), pH 7.4.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Car9 carbonic anhydrase 9 [ Mus musculus (house mouse) ]
Official Symbol : Car9
Synonyms : Car9; carbonic anhydrase 9; Ca9; CAIX; MN/CA9; CA-IX; carbonate dehydratase IX; carbonic anhydrase IX; membrane antigen MN homolog
Gene ID : 230099
mRNA Refseq : NM_139305.2
Protein Refseq : NP_647466.2
UniProt ID : Q8VHB5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What signaling pathways are known to regulate CA9 expression? 06/15/2022

The HIF-1 signaling pathway primarily regulates CA9 in response to cellular oxygen levels.

How does CA9 contribute to pH regulation within the tumor microenvironment? 02/02/2022

CA9 aids in extracellular acidification, promoting tumor cell survival and invasion in acidic tumor microenvironments.

How is CA9 expression regulated in hypoxic conditions? 04/15/2021

CA9 expression is upregulated by the hypoxia-inducible factor (HIF) under low oxygen conditions.

How are elevated levels of CA9 associated with cancer prognosis? 05/26/2020

Elevated CA9 levels often correlate with poor prognosis in various cancers due to its role in tumor adaptation to hypoxia.

What post-translational modifications have been identified on CA9? 11/23/2017

Potential modifications like glycosylation can be identified using techniques like mass spectrometry.

Are there specific inhibitors that target CA9, especially in cancer therapeutics? 09/29/2017

Several inhibitors, like acetazolamide derivatives, have been explored to target CA9 in cancer treatment.

What roles does CA9 play in tumor physiology? 07/06/2017

CA9 helps tumors survive in hypoxic conditions by regulating pH through the conversion of CO2 to bicarbonate and protons.

Customer Reviews (3)

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Reviews
08/04/2022

    Exceptional consistency, vital for our research's reliability.

    12/16/2021

      Critical support for our protein analysis and quantification.

      02/07/2021

        Unmatched accuracy in protein identification and sequencing.

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