Recombinant mouse Carboxypeptidase E,His-tagged

Cat.No. : CPE-2891M
Product Overview : Recombinant MouseCarboxypeptidase E (rmCPE), Met1-Phe476 fused with 6×his tag at C-terminuswas expressed in human HEK293 cells
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Cat. No. : CPE-2891M
Description : CarboxypeptidaseE (CPE), also known as Carboxypeptidase H or enkephalin convertase.Carboxypeptidase E cleaves C-terminal amino acid residues and is involved inneuropeptide processing. It is a peripheral membrane protein. CPEspecifically binds regulated secretory pathway proteins, includingprohormones, but not constitutively secreted proteins. Carboxypeptidase Eappears to have several functions. The active form of carboxypeptidase E wasshown to be in secretory vesicles, where it acts as an exopeptidase toactivate neuropeptides, It does that by cleaving off basic C-terminal aminoacids, producing the active form of the peptide. Products of carboxypeptidaseE include insulin, enkephalin, and most other neuroendocrine peptides.It hasalso been proposed that membrane-associated carboxypeptidase E acts as asorting signal for regulated secretory proteins in the trans-Golgi network ofthe pituitary and in secretory granules; regulated secretory proteins aremostly hormones and neuropeptides. Mice with mutant carboxypeptidase E Cpe,display endocrine disorders like obesity and infertility.
Source : Human HEK293 cells
Formulation : Bulk protein in a0.22 μm filtered solution of PBS, pH 7.4 and delivered as liquid formulationor lyophilized powder.Normally 5-8% trehalose and mannitol are added asprotectants before lyophilization.
Predicted N-terminal : Gln28
Species : Mouse
Purify : >95% asdetermined by SDS-PAGE. All lots are greater than 95% pure.
Storage : Store at -20℃ in lyophilizedstate after receipt. For long term storage, upon reconstitution rmCPE shouldbe aliquot and store at -20℃ or -80℃. Avoid repeated freeze-thaw cycles.
Gene Name : Cpe carboxypeptidase E [Mus musculus ]
Official Symbol : Cpe
Synonyms : Cpe;carboxypeptidase E; carboxypeptidase E; carboxypeptidase E; carboxypeptidaseH; enkephalin convertase; prohormone-processing carboxypeptidase
Gene ID : 12876
mRNA Refseq : NM_013494
Protein Refseq : NP_038522
MIM : 31395
UniProt ID : Q00493
Chromosome Location : 8 B3.1
Pathway : Diabetes pathways; Disease; InsulinSynthesis and Processing; Type I diabetes mellitus; Type I diabetes mellitus
Function : carboxypeptidase activity; celladhesion molecule binding; cobalt ion binding; hydrolase activity; metal ionbinding; metallocarboxypeptidase activity; metallopeptidase activity;neurexin family protein binding; peptidase activity; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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