Recombinant Mouse Card14 Protein, Myc/DDK-tagged

• Cat.No.: Card14-1963M
• Product Overview: Purified recombinant protein of mouse full-length caspase recruitment domain family, member 14 (Card14), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 113.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Card14 caspase recruitment domain family, member 14 [ Mus musculus (house mouse) ]
• Official Symbol: Card14
• Synonyms: CARD14; caspase recruitment domain family, member 14; caspase recruitment domain-containing protein 14; bcl10-interacting MAGUK protein 2; Bimp2; CARMA2
• Gene ID: 170720
• mRNA Refseq: NM_130886
• Protein Refseq: NP_570956
• UniProt ID: Q99KF0