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Recombinant Mouse Casp9 Protein, MYC/DDK-tagged

Cat.No. : Casp9-773M
Product Overview : Purified recombinant protein of full-length mouse caspase 9 (Casp9), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, the initiator caspase, is activated after cytochrome c release from mitochondria and targets downstream effectors. In mouse, deficiency of this gene can cause perinatal lethality. This protein may have a role in normal brain development. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 50 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Casp9 caspase 9 [ Mus musculus (house mouse) ]
Official Symbol : Casp9
Synonyms : Casp9; caspase 9; Mch6; APAF-3; CASP-9; AI115399; AW493809; ICE-LAP6; Caspase-9; caspase-9; ICE-like apoptotic protease 6; apoptotic protease Mch-6; apoptotic protease-activating factor 3; EC 3.4.22.62
Gene ID : 12371
mRNA Refseq : NM_015733
Protein Refseq : NP_056548
UniProt ID : Q8C3Q9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What clinical conditions are associated with dysregulation of CASP9 protein? 10/10/2022

Dysregulation of CASP9 protein is associated with cancer, neurodegenerative diseases, and immune system disorders.

Can CASP9 protein be used as a therapeutic target in autoimmune diseases? 01/16/2021

CASP9 protein is being investigated as a potential therapeutic target in autoimmune diseases to modulate immune cell apoptosis.

How is CASP9 protein implicated in immune system disorders? 10/01/2017

Dysregulation of CASP9 protein can lead to abnormal immune cell apoptosis, contributing to autoimmune diseases and immunodeficiency.

How is CASP9 protein targeted in cancer therapy? 09/06/2017

CASP9 protein is targeted using small molecule inhibitors and therapeutic antibodies to induce apoptosis in cancer cells.

Are there any genetic variations in the CASP9 gene that affect protein function? 08/18/2017

Yes, genetic variations in the CASP9 gene can impact protein function and have been linked to disease susceptibility.

Customer Reviews (3)

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Reviews
04/12/2023

    Its purity and consistency have provided me with reliable and reproducible results, ensuring the accuracy of my research findings.

    04/27/2020

      Their expertise and guidance have helped overcome hurdles, ensuring the smooth progress of my research.

      10/27/2016

        The bands of proteins in Western Blotting experiments were very clear.

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