Recombinant Mouse Cd274 protein, mouse IgG2a Fc-tagged

Cat.No.: Cd274-359M
Product Overview: Mouse PD-L1 / B7-H1 Protein, mouse IgG2a Fc Tag, low endotoxin, Phe 19 - Thr 238 (Accession # NP_068693) was produced in human 293 cells (HEK293).
Description: Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
Source: HEK293
Species: Mouse
Tag : mouse IgG2a Fc
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 51.8 kDa. The protein migrates as 65-85 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
Protein length: Phe 19 - Thr 238
Endotoxin: Less than 0.1 EU per μg by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).
Storage buffer: PBS, pH7.4
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Shipping: Powder,RT
Gene Name: Cd274 CD274 antigen [ Mus musculus (house mouse) ]
Official Symbol: Cd274
Synonyms: B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik; B7 homolog 1; PDCD1 ligand 1
Gene ID: 60533
mRNA Refseq: NM_021893.3
Protein Refseq: NP_068693.1
UniProt ID: Q9EP73

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