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Recombinant Mouse Cd55 Protein, His-tagged

Cat.No. : Cd55-7191M
Product Overview : Recombinant Mouse Cd55 Protein with a His tag.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety. Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition. Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis. This gene is located adjacent to a closely related gene on chromosome 1.
Species : Mouse
Tag : His
Form : Liquid
Molecular Mass : 36.8 kDa
Protein length : 35-362
AA Sequence : DCGPPPDIPNARPILGRHSKFAEQS KVAYSCNNGFKQVPDKSNIVVCLEN GQWSSHETFCEKSCVAPERLSFASL KKEYLNMNFFPVGTIVEYECRPGFR KQPPLPGKATCLEDLVWSPVAQFCK KKSCPNPKDLDNGHINIPTGILFGS EINFSCNPGYRLVGVSSTFCSVTGN TVDWDDEFPVCTEIHCPEPPKINNG IMRGESDSYTYSQVVTYSCDKGFIL VGNASIYCTVSKSDVGQWSSPPPRC IEKSKVPTKKPTINVPSTGTPSTPQ KPTTESVPNPGDQPTPQKPSTVKVS ATQHVPVTKTTVRHPIRTSTDKGEP NTGLEHHHHHH
Endotoxin : < 1.0 EU/μg of protein (determined by LAL method)
Purity : > 95 % by SDS-PAGE
Stability : Shelf life: one year from despatch.
Storage : Store undiluted at 2-8 centigrade for one week or (in aliquots) at -20 to -80 centigrade for longer. Avoid repeated freezing and thawing.
Concentration : 0.5 mg/mL (determined by absorbance at 280nm)
Storage Buffer : Phosphate Buffered Saline (pH 7.4) containing 10 % glycerol.
Gene Name : Cd55 CD55 molecule, decay accelerating factor for complement [ Mus musculus (house mouse) ]
Official Symbol : Cd55
Synonyms : Cd55; CD55 molecule, decay accelerating factor for complement; Daf; Daf-; Daf1; GPI-; Daf-GPI; GPI-DAF; complement decay-accelerating factor, GPI-anchored; CD55 antigen; Cromer blood group; GPI anchor addition signal; complement-glycosylphosphatidylinositol; decay accelerating factor 1
Gene ID : 13136
mRNA Refseq : NM_010016
Protein Refseq : NP_034146
UniProt ID : Q61475

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How do genetic variations in CD55 influence susceptibility to complement-mediated disorders, and what are the molecular mechanisms involved? 03/28/2022

Genetic variations in CD55 may influence susceptibility to complement-mediated disorders by affecting the protein's ability to regulate complement activation. This can lead to conditions like paroxysmal nocturnal hemoglobinuria (PNH).

How does CD55 contribute to the modulation of immune responses beyond its role in complement regulation? 05/22/2021

CD55 has immunomodulatory functions beyond complement regulation, influencing T cell responses and contributing to the maintenance of immune tolerance.

What role does CD55 play in protecting cells from complement-mediated lysis, and how does it contribute to immune evasion? 08/09/2019

CD55 protects cells from complement-mediated lysis by preventing the formation of membrane attack complexes. This contributes to immune evasion by pathogens and self-cells alike.

Can you elaborate on the structural domains of CD55 and how they mediate its interactions with complement components? 03/14/2018

CD55 consists of extracellular domains responsible for interactions with complement proteins, particularly C3b and C4b. These interactions prevent the formation of membrane attack complexes on host cells.

Can you discuss the involvement of CD55 in various diseases, including autoimmune disorders and infectious diseases? 01/06/2018

CD55 dysregulation is associated with autoimmune disorders, where it may contribute to immune system overactivity. Additionally, some pathogens exploit CD55 to evade host immune responses.

Customer Reviews (3)

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Reviews
02/23/2022

    Efficient shipping and exceptional product quality. This company knows how to serve its customers.

    09/20/2019

      Consistency is key in research, and this product delivers that every time.

      03/02/2018

        We've tried various proteins, but this one stands out for its purity and performance.

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