Recombinant Mouse Chfr Protein, Myc/DDK-tagged
Cat.No. : | Chfr-2142M |
Product Overview : | Purified recombinant protein of mouse full-length checkpoint with forkhead and ring finger domains (Chfr), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 74.3 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Chfr checkpoint with forkhead and ring finger domains [ Mus musculus (house mouse) ] |
Official Symbol : | Chfr |
Synonyms : | CHFR; checkpoint with forkhead and ring finger domains; E3 ubiquitin-protein ligase CHFR; checkpoint with forkhead and RING finger domains protein; RNF116; C230082M18; 5730484M20Rik |
Gene ID : | 231600 |
mRNA Refseq : | NM_172717 |
Protein Refseq : | NP_766305 |
UniProt ID : | Q810L3 |
Products Types
◆ Recombinant Protein | ||
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CHFR-1638M | Recombinant Mouse CHFR Protein, His (Fc)-Avi-tagged | +Inquiry |
CHFR-0422H | Recombinant Human CHFR Protein (E2-N664), Tag Free | +Inquiry |
CHFR-0423H | Recombinant Human CHFR Protein (E2-N664), His tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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